Essays about: "Breast Stroma"

Found 4 essays containing the words Breast Stroma.

  1. 1. Can the selective PDGF-receptor antagonist STI571 reduce hypoxia in solid tumors, and enhance drug uptake of Taxol, by lowering the interstitial fluid pressure in stroma rich breast carcinoma, BT-474

    University essay from Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Author : Marcus Runeson; [2015]
    Keywords : ;

    Abstract : Background Solid tumors have high interstitial fluid pressure, IFP. This cause a dramatic loss in uptake of anti cancer drugs with poor clinical outcome as result. Treatment with PDGF-receptor antagonist STI-571 lowers tumor IFP and enhances uptake of small compounds. READ MORE

  3. 2. In situ molecular profilling of the microenvironment of breast carcinoma

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Mustapha Kaira; [2015]
    Keywords : Sequencing; gene expression analysis; cancer genetics; RCA; padlock probe;

    Abstract : High stromal PDGF receptor B expression was shown to have strong prognostic value in a studyinvolving over 600 breast cancer patients however, the molecular role of the receptor in tumordevelopment remains unclear. In this project we studied the spatial distribution and expressionlevels of a panel genes and markers associated with PDGF signaling, in breast cancer tumormicroenvironment (TME) using a newly developed technique -in situ sequencing. READ MORE

  4. 3. TGF-β (BETA) AND PERIOSTIN MODULATE EACH OTHER’S EXPRESSION IN BOTH BREAST STROMA AND TUMOR CELLS

    University essay from Institutionen för vård och natur

    Author : Anindita Das Burman; [2013]
    Keywords : TGF-β; Periostin; Breast Stroma; Breast Tumor; Tumor Microenvironment;

    Abstract : Breast cancer is the most common cancer in female population worldwide. In addition to mutations, the breast tumor microenvironment especially the tumor cell - stroma interactions through extracellular matrix components and multiple growth factors have been shown to promote tumor progression. READ MORE

  5. 4. Immunohistochemical detection of thymidine kinase 1 in canine mammary tumors and lymphomas

    University essay from SLU/Dept. of Clinical Sciences

    Author : Alexandra Leijon; [2013]
    Keywords : mammary tumor; lymphoma; dog; cacine; thymidine kinase;

    Abstract : The dog has often served as a model animal for humans in scientific studies. This is due to the fact that dogs are susceptible to a wide range of diseases which also affect humans. One example is cancer, a condition that affects dogs as well as owners. Neoplastic diseases account for 18-23 % of all deaths in dogs (Bonnet et al. READ MORE