Essays about: "HepG2"
Showing result 1 - 5 of 11 essays containing the word HepG2.
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1. Development of Microfluidic 3D Cell Culture with a Nanocellulose-Based Scaffold for Spheroid Formation as a Potential Tool for Drug Screening
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : Abstract Lack of clinical relevance is assumed to be the main reason behind the high failure rate of medical drugs in the very initial phases of clinical trials. Clinical relevance is difficult to achieve with current tools as they lack the biological and physiological cues found in vivo. READ MORE
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2. Predicting Mechanisms of Toxicity for Drug Development
University essay from Göteborgs universitet/Institutionen för data- och informationsteknikAbstract : The aim of this thesis is to predict different mechanisms of toxicity from the metabolomic response of HepG2 liver cells. In order to utilize the metabolomic data the a semisupervised machine learning approach is investigated, namely the cluster-then-label approach. READ MORE
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3. Analysis of hydrogels for immobilisation of hepatocytes (HepG2) in 3D cell culturing systems
University essay from Linköpings universitet/Teknisk biologiAbstract : In pharmaceutical development cell cultures are used as in vitro models to evaluate the function of drug candidates. In such research it is vital to have models that resemble the in vivo environment to get reliable results. READ MORE
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4. Development of a combined In-Cell ELISA and flow cytometry method for quantification of uptake of PEGylated nanoparticles by Raw264.7 and HepG2 cells
University essay from Lunds universitet/Tillämpad biokemiAbstract : Cancer is one of today’s most common causes of human mortality. For long, chemotherapeutics has been a conventional treatment of the disease, but due to its low precision and high frequency of side effects, this treatment has been highly debated. READ MORE
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5. In Vitro Studies on the Uptake of Ion-X-Gel Precursor and SPIO by Various Cell Types
University essay from Lunds universitet/Examensarbeten i molekylärbiologiAbstract : Abstract Contrast agents for MRI can greatly improve the contrast in the image, making it easier to pinpoint the position of, for example, inflamed tissues or tumors. There is a need for novel contrast agents with better spatial resolution, higher sensitivity, fewer false positives and lower toxicity. READ MORE