Essays about: "Hepatocyte"

Showing result 1 - 5 of 7 essays containing the word Hepatocyte.

  1. 1. Characterization of hepatocyte derived metabolites of various New Psychoactive Substances using LC-QTOF-MS.

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Sarah Ingvarsson; [2020]
    Keywords : 4-fluoro-CUMYL-5-fluoro-PICA; synthetic cannabinoid; incubation; metabolites.;

    Abstract : New psychoactive substances are becoming increasingly common in many parts of the world, and some of them are marketed as “legal highs” and are produced to circumvent the drug legislation, and they come in many unregulated forms. The aim of this research was to characterize the metabolites of a new psychoactive substance and hence provide the fundamental data needed for further research of toxicity and future drug testing. READ MORE

  3. 2. Analysis of hydrogels for immobilisation of hepatocytes (HepG2) in 3D cell culturing systems

    University essay from Linköpings universitet/Teknisk biologi

    Author : Elisabeth Westergren; [2018]
    Keywords : Hydrogel; Hepatocyte; Tuneable; PEG-peptide; 3D cell culture;

    Abstract : In pharmaceutical development cell cultures are used as in vitro models to evaluate the function of drug candidates. In such research it is vital to have models that resemble the in vivo environment to get reliable results. READ MORE

  4. 3. Assessment of new tracers targeting c-Met for therapeutic effects and possible radioimmunotherapy

    University essay from Uppsala universitet/Institutionen för immunologi, genetik och patologi

    Author : Caroline Lillkull; [2018]
    Keywords : ;

    Abstract : c-Met is a receptor tyrosine kinase that is activated by its ligand hepatocyte growth factor (HGF). c-Met is overexpressed or subject to abnormal activation through mutations or disrupted signaling pathways in various cancers, making it an attractive target for drug therapy with additional potential for imaging properties. READ MORE

  5. 4. Development of a combined In-Cell ELISA and flow cytometry method for quantification of uptake of PEGylated nanoparticles by Raw264.7 and HepG2 cells

    University essay from Lunds universitet/Tillämpad biokemi

    Author : Evelina Folkesson; [2016]
    Keywords : HepG2; Raw264.7; PEGylation; PEG; cancer; nanoparticles; In-Cell ELISA; flow cytometry; applied biochemistry; tillämpad biokemi; Technology and Engineering;

    Abstract : Cancer is one of today’s most common causes of human mortality. For long, chemotherapeutics has been a conventional treatment of the disease, but due to its low precision and high frequency of side effects, this treatment has been highly debated. READ MORE

  6. 5. Akut mikrocystinförgiftning hos däggdjur

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Josefine Löfgren; [2013]
    Keywords : cyantotoxin; microcystin; absorption; distribution; metabolism; elimination; toxicitet; mekanismer; effekter;

    Abstract : Förgiftningar hos däggdjur som druckit vatten kontaminerat med cyanotoxiner har observerats världen över, och riskerar att öka i takt med tilltagande övergödning och klimatförändringar. Denna litteraturstudie inriktar sig på mikrocystin (MC) som är det vanligaste och mest studerade cyanotoxinet. READ MORE