Essays about: "Lipid formulation"

Showing result 1 - 5 of 9 essays containing the words Lipid formulation.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Author : Elina Edidovica; [2024]
    Keywords : Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Abstract : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. READ MORE

  3. 2. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    University essay from Lunds universitet/Kemiteknik (CI)

    Author : Owais Khalil; [2023]
    Keywords : Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Abstract : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. READ MORE

  4. 3. Formulation and characterization of lipid-based nanocarriers for the delivery of antimicrobial peptide

    University essay from KTH/Proteinvetenskap

    Author : Srijani Saha; [2022]
    Keywords : AP114; Antimicrobial peptide AMP ; Nanostructured lipid carriers NLC ; Liposomes; Dynamic light scattering DLS ; Hydrodynamic size distribution; Zeta potential; Entrapment efficiency EE ; Release study;

    Abstract : Bakterier som är resistenta mot antibiotika har de senaste åren blivit ett stort hot mot mänskligheten. Att utveckla nya antibiotikaläkemedel är väldigt tidskrävande samt kommer med en dyr prislapp. READ MORE

  5. 4. In vitro performance prediction of LBFs using lipolysis-permeation assay with the LiDo artificial membrane: Validation and protocol optimization

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Alaa Zangana; [2021]
    Keywords : ;

    Abstract : Lipid-based formulations (LBFs) can be an effective formulation strategy to improve the bioavailability of lipophilic drugs. However, conventional single-compartment in vitro lipolysis assays often underestimate LBF performance in vivodue to the absence of absorption sink. READ MORE

  6. 5. Effect of lipid-based formulation on the solubilization patterns if poorly water-soluble drugs.

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Manjiri Gude; [2021]
    Keywords : Lipid based formulations LBFs ; poorly water-soluble drugs PWSDs ; solubility studies; coarse grained molecular dynamic simulations; solubilization; dog intestinal fluid DIF ;

    Abstract : Poorly water-soluble drugs (PWSDs), to date, require advanced formulation techniques to improve solubility and achieve the required plasma concentration to show a therapeutic effect when orally administered. Lipid-based formulations (LBFs) are an enabling strategy that is being used to improve the oral delivery of PWSDs. READ MORE