Essays about: "RNA polymerase"

Showing result 1 - 5 of 23 essays containing the words RNA polymerase.

  1. 1. Development of ultra-sensitive immunoassay on Gyrolab microfluidic platform using Binding Oligo Ladder Detection : Enhancing Gyrolab biomarker assays using Exazym®

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Sam Vadi Dris; [2024]
    Keywords : Immnoassay; Gyrolab; TNF-alpha; Ultra-sensitive; Cavidi; Exazym; BOLD amplification; Amplification;

    Abstract : Immunoassays are widely used for detection of antigens in a wide range of applications including assays in pharmaceutical development. Immunoassays are continuously improved in many aspects including automatization, miniaturization and extending the dynamic range. READ MORE

  3. 2. Developing Wastewater-based Early Warning System for the Detection of Disease Outbreaks and Emerging Variants with focus on SARS-CoV-2

    University essay from KTH/Industriell bioteknologi

    Author : Ayda Kiyar; [2023]
    Keywords : wastewater-based epidemiology; early warning system; RT-qPCR; normalization; SARS-CoV-2; avloppsvattenbaserad epidemiologi; förvarningssystem; RT-qPCR; normalisering;

    Abstract : Under covid-19-pandemin har avloppsvattenbaserad epidemiologi (WBE) använts i stor utsträckning som ett komplement till kliniska tester över många delar av världen. Detta projekt syftade till att detektera och kvantifiera belastningen av Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) i avloppsvattenprover med hjälp av Revers transkriptas kvantitativ polymeraskedjereaktion (RT-qPCR). READ MORE

  4. 3. Towards time-resolved cryo-EM of SARS-CoV-2 replication-transcription complex and Staphylococcus aureus DNA gyrase

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Anna Králová; [2023]
    Keywords : time-resolved cryo-EM; DNA gyrase; SARS-CoV-2; replication-transcription complex; protein purification;

    Abstract : Time-resolved cryo-EM has already provided ground-breaking discoveries in various fields, including structural biology, biochemistry, and drug development. Compared to traditional structural biology methods where mostly stabilized conformations are reconstructed, the main advantage of time-resolved cryo-EM is its ability to capture dynamic processes in biological samples at near-atomic resolution, which allows for studying biological structures as they change and interact in real-time. READ MORE

  5. 4. Computational Pipeline for Analyses of Genome-Wide Nascent Transcription from PRO-seq Data

    University essay from KTH/Genteknologi

    Author : Serhat Aktay; [2023]
    Keywords : Transcription; functional genomic regions; heat shock response; computational pipeline development; automation.; Genavläsning; genomets funktionella regioner; värmechockrespons; dataanalysutveckling; automatisering;

    Abstract : Celler har en rad olika sätt att försvara sig mot stress för att överleva, främst genom att reglera transkriptionen av gener. En metod för att undersöka hur cellens transkription förändras vid cellulär stress är precision run-on sequencing (PRO-seq). READ MORE

  6. 5. Understanding the pathophysiology ofrecurrent UBTF mutations associated withpediatric AML

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Annie Paulsson; [2022]
    Keywords : Hematologi; Cancer; AML; UBTF; leukemi;

    Abstract : Acute myeloid leukaemia (AML) is highly heterogeneous haematological malignancy, which represents a challenge in the understanding of the disease. Relapse in AML is common, andmany relapsed patients respond poorly to conventional treatment, leading to a low survivalrate. READ MORE