Essays about: "cell library"

Showing result 1 - 5 of 55 essays containing the words cell library.

  1. 1. Effects of phosphorylation on the ADP-ribosylation activity of PARP16

    University essay from Lunds universitet/Kemiska institutionen

    Author : Virginia Martín Cristóbal; [2023]
    Keywords : ADP-ribosylation; Kinases; PARP16; Phosphorylation; UPR biochemistry; Biochemistry; Chemistry;

    Abstract : PARP16/ARTD15 is an intracellular mono-ADP-ribosyltransferase that catalyzes auto- and heteromodification by transfer of a single ADP-ribose moiety. It belongs to the ADP-ribosyltransferase (ART) superfamily. READ MORE

  3. 2. CRISPR Screen to Identify Genes Regulating Melanoma Cell Invasiveness

    University essay from KTH/Proteinvetenskap

    Author : Emma Kroon; [2023]
    Keywords : CRISPR-Cas9; gene knockout; viral packaging; transduction; invasionstest; CRISPR-Cas9; genknockout; viruspackning; transduction; invasion assay;

    Abstract : Maligna cancerceller har förmågan att sprida sig okontrollerat i kroppen och metastasera till avlägsna organ. Kritiskt i metastaserings processen är cancercellers förmåga att invadera närliggande vävnader innan de sprider sig vidare ut i kroppen. READ MORE

  4. 3. Generation of a new ADAPT library for stability improvement

    University essay from KTH/Proteinvetenskap

    Author : Sumant Yogesh Salphale; [2023]
    Keywords : Phage display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; protein engineering; cancer detection; Fag-display; CEACAM5; EpCAM; Trop2; ADAPT; ABD; proteinteknik; cancerdetektion;

    Abstract : Under senare år har målinriktad terapi varit ett växande område inom cancerterapi som en mer målinriktad behandling än kemoterapi. Dessa behandlingar baseras främst på antikroppsbaserade läkemedel som är ganska stora och komplexa, vilket ökar den totala kostnaden för behandlingen. READ MORE

  5. 4. Multi-Scale Topology Optimization of Lattice Structures Using Machine Learning

    University essay from Uppsala universitet/Tillämpad mekanik

    Author : Julia Ibstedt; [2023]
    Keywords : Topology optimization; Multi-scale topology optimization; Machine learning; Gaussian process; Homogenization; Inverse homogenization; Anisotropic materials; Symmetry groups; Material property space; Topologioptimering; Flerskalig topologioptimering; Maskininlärning; Gaussian process; Homogenisering; Anisotropa material; Symmetrigrupper; Materialegenskapsrymd;

    Abstract : This thesis explores using multi-scale topology optimization (TO) by utilizing inverse homogenization to automate the adjustment of each unit-cell's geometry and placement in a lattice structure within a pressure vessel (the design domain) to achieve desired structural properties. The aim is to find the optimal material distribution within the design domain as well as desired material properties at each discretized element and use machine learning (ML) to map microstructures with corresponding prescribed effective properties. READ MORE

  6. 5. Compounds screening for the identification of novel drug to improve the Knock in efficiency mediated by CRISPR-Cas9

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Evangelia Anagnostou; [2023]
    Keywords : Genome editing; Knock in; HDR; CRISPR-Cas9; screening; NHEJ;

    Abstract : Genome editing is an exciting field that allows for the precise modification of an organism's DNA. One of the most advanced tools in this area is CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9), which creates a DSB (Double-strand break) at a specific location in the genome. READ MORE