Essays about: "pharmaceutical distribution"

Showing result 1 - 5 of 38 essays containing the words pharmaceutical distribution.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    University essay from Uppsala universitet/Analytisk kemi

    Author : Maryam Dost; [2024]
    Keywords : Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Abstract : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. READ MORE

  3. 2. Methods to study device induced aggregation of proteins

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Marie Therese von Wowern; [2023]
    Keywords : protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

    Abstract : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. READ MORE

  4. 3. The Potential Use of Degradable Starch Microspheres as a Carrier for Nasal Drug Administration

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Rojda Unal; [2023]
    Keywords : Pharmaceutical technology; Nasal administration; Läkemedel; Pulverformiga bärare; Sfärer; Pulverinhalation; Bärarmaterial; Läkemedelseffektivitet; Pulverteknik; Partikelformulering; Nasal deposition; Biology and Life Sciences;

    Abstract : Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. READ MORE

  5. 4. The effect of lactose fines, magnesium stearate, choice of mixer and mixing process on the performance of adhesive mixtures for inhalation

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Gabriela Ponce Aparicio; [2023]
    Keywords : High shear mixing; low shear mixing; lactose fines; coating agent; budesonide; mixing energy; dry powder inhaler; carrier-based formulations; mixing time; adhesive mixtures; pharmaceutical technology; Technology and Engineering;

    Abstract : Dry powder inhaler (DPI) formulation is a major area of interest since they are employed by the healthcare system to treat relevant chronic diseases like asthma. Previous research has established that the manufacturing process and formulation composition are key for the active pharmaceutical ingredient to reach the lungs and achieve therapeutic effects. READ MORE

  6. 5. Storage period optimization of a viscous nasal spray suspension

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Lili Zsófia Domián; [2023]
    Keywords : Rhinocort; viscosity; rheology; thixotropy; pharmaceutical technology; Technology and Engineering;

    Abstract : The number of people suffering from the unpleasant symptoms of allergic rhinitis is increasing due to environmental and other factors. This not only makes life difficult for the individual but also places a heavy burden on society, which is why treatment is needed. READ MORE