MembraneLogic - A database to couple membrane protein sequences to variation and disease

Abstract: Bioinformatics data is growing faster than exponentially. This large amount of data hasopened up many possibilities but it also poses many challenges as it is a tedious task tomanually analyze this data.
25% of our genes translates to membrane proteins and they contain 60% of the drugtargets. A genetic variation can alter the function of a protein, this can sometimes lead to adisease. Knowing where in the protein structure a disease causing variation occurs will aiddrug designers in the drug discovery process.
MembraneLogic is a database that through its automated data gathering process identifiesthe membrane proteins by prediction and links them to known SNPs and their relation todisease.
The data it uses comes from NCBI Ensembl and PDB and the main prediction methodused to identify membrane proteins is SCAMPI.
Its web interface provides functionality to search for membrane proteins and diseases andsee what variations are related to disease ,both in sequence and structure.The application is implemented with JAVA platform related tools and frameworks such asGrails, Spring and Hibernate.