Essays about: "ABC-transporter"

Showing result 1 - 5 of 10 essays containing the word ABC-transporter.

  1. 1. In silico and in vitro determination of substrate specificity for Breast Cancer Resistance Protein (BCRP) transporter at the blood-brain barrier

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Fen Wang; [2021]
    Keywords : BCRP; substrate specificity; BBB; ATP-binding cassette ABC transporter; Drug transport;

    Abstract : Background The Breast Cancer Resistance Protein (BCRP) drug transporter is important for drug disposition and plays a critical role in regulating drug entry into the brain. Its substrate spectrum overlaps with substrates of Multi Drug Resistance Protein 1 (MDR1, P-gp), which influences and complicates the interpretation of data on drug distribution into tissues (e. READ MORE

  3. 2. The expression of ABC transporter in colorectal cancer : A study about ABCC5 and ABCC11 gene expression in colorectal cancer

    University essay from Högskolan i Skövde/Institutionen för hälsovetenskaper

    Author : Anny Inamahoro; [2020]
    Keywords : ;

    Abstract : Introduction. Stage III colorectal cancer is treated with adjuvant chemotherapy based on 5-fluorouracil and leucovorin. Drug resistance to anticancer treatment might be due to adenosine triphosphate binding cassette transporter family members.Aim. READ MORE

  4. 3. An in vitro model for studying gene expression in Parascaris univalens larvae

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Sofia Jonsson; [2019]
    Keywords : Parascaris univalens; equine roundworm; Parascaris; Parascaris univalens larvae; anthelmintic resistance; drug metabolism; gene expression; in vitro model; ivermectin.;

    Abstract : Parascaris univalens, equine roundworm, is a large nematode infecting young horses and causes respiratory syndromes, impaired condition and reduced growth. Adults can reach up to 50 cm in length and heavy infection can lead to obstruction and rupture of the small intestines due to the worm’s size. READ MORE

  5. 4. Mekanismer för resistens mot makrocykliska laktoner

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Johan Sjöstedt; [2017]
    Keywords : Resistens; makrocykliska laktoner; Caenorhabditis elegans; Haemonchus contortus; Cooperia oncophora; Resistance; macrocyclic lactones;

    Abstract : Makrocykliska laktoner (ML) är ett viktig anthelmintika som används mycket. Den utbredda användningen har lett till att nematoder har utvecklat läkemedelsresistens. För att bekämpa det måste nya metoder tas fram för att hitta genetiska markörer som på ett tidigt stadie kan identifiera resistenta nematoder. READ MORE

  6. 5. P-glykoproteins betydelse vid metabolism och resistensutveckling mot makrocykliska laktoner

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Caroline Linderholt; [2013]
    Keywords : P-glykoprotein; nematoder; makrocykliska laktoner; resistens; ivermektin;

    Abstract : Parasiter i magtarmkanalen och framför allt nematoder, orsakar världsomfattande produktionsförluster hos lantbrukets djur. För att kontrollera nematodinfektioner används anthelmintika. En överanvändning av anthelmintika har resulterat i att vissa nematoder utvecklat resistens. READ MORE