Essays about: "ABD-Derived Affinity ProTeins ADAPT"

Found 4 essays containing the words ABD-Derived Affinity ProTeins ADAPT.

1. 1. Optimization of immunotherapeutic relevant ABD-derived affinity proteins for prolonged serum half-life

   University essay from KTH/Proteinvetenskap

   Author : Ebba Bergström; [2022]
   Keywords : Half-Life extension; Human serum Albumin HSA ; Interleukin 17c IL17c ; ABD-Derived Affinity ProTeins ADAPT ; Protein-based drugs.;

   Abstract : Marknaden för proteinbaserade läkemedel, de så kallade biologiska läkemedlen, är idag en industri som omsätter miljarder. Ett vanligt sätt att utveckla dessa läkemedel på är med hjälp av monoklonala antikroppar då de kan binda till sitt mål med hög specificitet. READ MORE

3. 2. Investigation of possible improvements of the stability of bispecific ADAPT proteins

   University essay from KTH/Proteinvetenskap

   Author : Ella Eriksson; [2021]
   Keywords : Protein purification; Affinity chromatography; ABD-derived domain; ADAPT protein; simultan binding;

   Abstract : The aim of the project was to identify positions and amino acids that contribute to improved structure and stability of bispecific ADAPT proteins. During the 20 weeks project period, different amino acid substitutions were analysed to evaluate the effect on the three-helical structure and stability of bispecific ADAPTs targeting human serum albumin (HSA) and tumor necrosis factor α (TNFα). READ MORE

4. 3. Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Jesper Borin; [2020]
   Keywords : ABD; ADAPT; HER2; CEACAM6; HSA; Phage display; Cancer therapy; Spatial bispecificity; Half-life extension; Biodistribution;

   Abstract : Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. READ MORE

5. 4. Production and characterization of alternative scaffold proteins for medical applications

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Axel Knave; [2020]
   Keywords : Protein Engineering; Affinity proteins; ABD; ADAPT; Interleukin 17;

   Abstract : Antibodies, as forerunners in the field of biological drugs, are originally an organism’s answer to the invasion of different pathogens. Today, antibodies are a common treatment for many chronic diseases such as the immune-mediated inflammatory diseases rheumatoid arthritis or psoriasis. READ MORE