Essays about: "ACQUITY UPLC BEH C18"

Found 2 essays containing the words ACQUITY UPLC BEH C18.

  1. 1. Development of separation method for analysis of oligonucleotides using LC-UV/MS

    University essay from Uppsala universitet/Analytisk farmaceutisk kemi

    Author : Björs Ida; [2018]
    Keywords : Oligonucleotides; UPLC; liquid chromatography; time of flight; mass spectrometry; reversed-phase weak anion exchange; AcclaimTM Mixed Mode WAX-1; DNAPacTM RP; ACQUITY UPLC BEH C18;

    Abstract : Introduction Oligonucleotides are short nucleic acid chains, usually 19-27mer long. They bind to their corresponding chain, making a specific inhibition possible. In pharmaceuticals, this can be used to inhibit the expression of a gene or protein of interest. READ MORE

  3. 2. Evaluation of a UPLC-MS method using 18O-labelled water for the identification of hydrolytic degradants of drug substances

    University essay from Uppsala universitet/Avdelningen för analytisk farmaceutisk kemi

    Author : Viktor Kjellberg; [2015]
    Keywords : hydrolysis; degradation; degradants; 18O; 18O-water; liquid chromatography; mass spectrometry; analytical chemistry; structure eludication;

    Abstract : In this master’s thesis the hydrolytic degradation in 18O-water solutions of six drug substances has been studied. The aim was to develop a mass spectrometric method for easier identification of degradants, since hydrolysis in 18O-water will generate degradants with higher mass compared with hydrolysis in regular water. READ MORE