Essays about: "Acid dissociation"

Showing result 1 - 5 of 11 essays containing the words Acid dissociation.

  1. 1. Machine learning for molecular property prediction and drug safety

    University essay from Göteborgs universitet/Institutionen för data- och informationsteknik

    Author : Kinga Jenei; [2023-10-23]
    Keywords : Molecular property prediction; Acid dissociation constant; pKa; Machine learning; Graph Neural Networks; Molecular descriptors; Drug Discovery;

    Abstract : Utilizing machine learning methods for the prediction of acid dissociation (pKa ) values of compounds holds great significance, as pKa is an important parameter, optimized frequently in drug discovery. Accurate prediction of pKa values could potentially provide valuable insights on other molecular properties and thereby support compound design. READ MORE

  3. 2. Characterisation of structure and stability differences between the C-lobes of human and P. falciparum calmodulin in the presence of calmidazolium

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Igor Blagojevic; Klara Enockson; Marcus Miras Landelius; Ylva Strid Holmertz; Emelie Weinesson; Emma Örnelöw; [2022]
    Keywords : Calmodulin; Calmidazolium; Plasmodium falciparum; Malaria; Fluorescence spectroscopy; UV spectroscopy; CD; Circular dichroism; bioinformatics;

    Abstract : Malaria is a serious disease that can lead to fatal consequences if not treated. It is mainly spread via Plasmodium falciparum, a parasite carried by mosquitoes as host organisms. As a potential way of treating malaria, research is being done on possible inhibitors of calmodulin (CaM) in the parasite. READ MORE

  4. 3. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins

    University essay from KTH/Proteinvetenskap

    Author : Carl Olsson; [2021]
    Keywords : Post synaptic density protein 95; PDZ-domains; N-methyl-D-aspartate receptor; NMDAR hypofunctional hypothesis; GluN2b; Differential scanning fluorimetry; Surface plasmon resonance; Fragment based drug design; Assay development;

    Abstract : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. READ MORE

  5. 4. Mitigating the impact of antidrug antibodies against insulin on ELISA assay

    University essay from Malmö universitet/Institutionen för biomedicinsk vetenskap (BMV)

    Author : Thea Bøwadt; [2021]
    Keywords : Enzyme-Linked Immunosorbent Assay; ELISA; Antidrug antibodies; ADA; Insulin; Polyethylene glycol; PEG; Acid dissociation; MgCl2.;

    Abstract : Diabetes has, in the past three decades, surged immensely. Because of this, new insulin analogues are constantly in the making.  In clinical studies, the presence of antidrug antibodies can prove a challenge when measuring insulin. READ MORE

  6. 5. Fragment screening using WAC towards new SMARCA4 inhibitors

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Artur Sahakjan; [2020]
    Keywords : WAC; Fragments; SMARCA4; Library; Fragment Based Drug Discovery FBDD ; Peptide Synthesis; Affinity; Organic chemistry; Organisk kemi; Chemistry;

    Abstract : The drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been implemented into different techniques with purpose of discovering new drugs. READ MORE