Essays about: "Adeno-associated virus"

Found 5 essays containing the words Adeno-associated virus.

  1. 1. Design and production of adeno-associated virus vectors for imaging mitochondrial networks in the brain

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Elnaz Samadian Zad; [2023]
    Keywords : adeno-associated virus; mitochondria; mitochondrial networks; imaging; fluorescent protein; synapsin promoter; human embryonic kidney cells; organoids;

    Abstract : Mitochondria are dynamic organelles that function in a complex interconnected network within the cell. Neurons are sensitive and highly energy demanding cells in the brain which require a functioning mitochondrial network that is able to provide ATP and modulate calcium. READ MORE

  3. 2. The future of viral vectors for gene therapy

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Elias Ekstedt; Inna Fryckstedt; Hanna Hyllander; Josefin Jonsson; Elin Ring; Felix Wærn; [2021]
    Keywords : Gene therapy; adenovirus; alpharetrovirus; baculovirus; adeno-associated virus; lentivirus; herpes simplex virus; foamy virus; gammaretrovirus;

    Abstract : Gene therapy is a fast growing technology that offers treatments for genetic diseases. The method is based on introducing genetic material into a patient to replace the disease-causing gene, using a vector. READ MORE

  4. 3. Development and comparison of three immunoassay formats to screen for total anti-adeno-associated virus serotype 2 antibodies in human serum using the Gyrolab immunoassay platform

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Elin Eriksson; [2020]
    Keywords : Adeno-associated virus; AAV; anti-AAV; TAb; Gyrolab; immunity; immunoassay;

    Abstract : Recombinant adeno-associated virus vectors are one of the most promising gene delivery tools for applications within gene- and cell therapy. The high level of wild-type adeno-associated virus infections in humans is a limitation due to the pre-existing immunity against the vector or its transgene product. READ MORE

  5. 4. Generella principer för virala vektorsystem och deras tillämpning inom veterinärmedicin

    University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Author : Josefin Brock von Rein; [2018]
    Keywords : viral vektor; genterapi; cancer; vaccin; veterinärmedicin;

    Abstract : Under lång tid betraktades virus enbart som ett hot mot djur och människor med stor risk att åsamka skada. Framgångar i molekylär virologi kom att bredda den uppfattningen och visa att den virala infektionsvägen var användbar för terapeutiska syften. READ MORE

  6. 5. Characterization of the synaptic connectivity patterns of genetically defined neuron types in circuits that regulate dopamine and serotonin

    University essay from KTH/Skolan för teknik och hälsa (STH)

    Author : Alexandros Ikaros Pavlopoulos; [2014]
    Keywords : neuroscience; lateral habenula; optogenetics; neuronal populations; neurons; brain; dopamine; serotonin; dual viral system; retrograde viral tracing; globus pallidus; rabies virus; reward; basal ganglia;

    Abstract : The Lateral Habenula (LHb) have been implicated in both reward-seeking behavior and in depressive disorders due to its modulatory effects on dopamine rich areas. Excitatory projections from LHb target GABAergic interneurons of both ventral tegmental area (VTA) and rostromedial tegmental nucleus (RMTg) and consequently provide strong inhibition on VTA‟s dopaminergic neurons. READ MORE