Essays about: "Affinity maturation"

Found 2 essays containing the words Affinity maturation.

  1. 1. Bacterial Display of a Tau-Binding Affibody Construct:Towards Affinity Maturation

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Moira Ek; [2020]
    Keywords : Microtubule-associated protein tau; Neurodegenerative disorders; Alzheimer’s disease; Affibody molecules; Affinity maturation; Staphylococcal surface display; Escherichia coli display; Flow cytometry; Cell sorting;

    Abstract : Aggregation of microtubule-associated protein tau is involved in the pathology of several neurodegenerative diseases, including Alzheimer’s disease. The affibody TP4 has been shown to inhibit this aggregation process, and its target-binding positions were previously grafted onto a dimeric affibody scaffold, creating the sequestrin seqTP4. READ MORE

  3. 2. Generation of affinity maturation libraries of PSMA targeting affibody molecules and selections to find improved binders

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Rebecka Stockgard; [2018]
    Keywords : ;

    Abstract : Prostate specific membrane antigen (PSMA) is a membrane protein expressed in both prostate cancer cells and in the neovasculature of many other solid tumors. It can act as a therapeutic target and as a target for an imaging agent for various cancers. READ MORE