Essays about: "BBB"

Showing result 1 - 5 of 21 essays containing the word BBB.

  1. 1. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Jonathan Efverström; [2023]
    Keywords : Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Abstract : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. READ MORE

  3. 2. The Potential Use of Degradable Starch Microspheres as a Carrier for Nasal Drug Administration

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Rojda Unal; [2023]
    Keywords : Pharmaceutical technology; Nasal administration; Läkemedel; Pulverformiga bärare; Sfärer; Pulverinhalation; Bärarmaterial; Läkemedelseffektivitet; Pulverteknik; Partikelformulering; Nasal deposition; Biology and Life Sciences;

    Abstract : Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. READ MORE

  4. 3. Sex-specific pathological response to Traumatic Brain Injury

    University essay from Lunds universitet/Examensarbeten i molekylärbiologi

    Author : Christopher Fry; [2022]
    Keywords : Biology and Life Sciences;

    Abstract : Traumatic brain injury (TBI) is one of leading causes of death in the world; survivors commonly exhibit behavioural changes and neurocognitive defects in the long-term. Following TBI, rapid changes in the neurovascular unit (NVU) occur as the permeability of the blood brain barrier (BBB) increases and cerebral blood flow (CBF) becomes dysregulated. READ MORE

  5. 4. An Assessment of the Riksbank’s Corporate Bond Purchase Program on the Yield Spread and Firm’s Debt Structure

    University essay from Lunds universitet/Nationalekonomiska institutionen

    Author : Najmeh Hajimirza; Nichawan Thamrongsak; [2022]
    Keywords : Quantitative easing; Corporate bond purchase program; Yield spread; Debt structure; Intention-to-treat; Treatment-on-treated; Business and Economics;

    Abstract : We study the effect of Riksbank’s corporate bond purchase program on the yield spread of bonds and firm-level debt structure. We find evidence that the Riksbank’s corporate quantitative easing announcement reduces the yield spread of eligible bonds compared to the non-eligible bonds. READ MORE

  6. 5. Developing a Method to Study the Impact of Microbial DNA on the Brain Related to Alzheimer’s Disease – Can Food Make a Change?

    University essay from Lunds universitet/Livsmedelsteknik och nutrition (master)

    Author : Fuh-Tzu Yang; [2022]
    Keywords : DNA extraction; Microbiome DNA enrichment; Host DNA depletion; 16S rRNA sequencing; Alzheimer’s disease; Gut-brain axis; Microbiota; Microbial DNA; Black currant; Applied Nutrition and Food Chemistry; Medicine and Health Sciences;

    Abstract : Understanding the gut-brain-microbiota axis can help us provide a new tool to manage conditions such as Alzheimer’s. However, a major challenge is selectively amplifying the bacterial DNA which is present at a much lower level than the host DNA. READ MORE