Essays about: "Cancer sequencing"

Showing result 1 - 5 of 41 essays containing the words Cancer sequencing.

  1. 1. Identification of Immunological Targets for Brain Cancer Immunotherapy

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Zhenda Wang; [2022]
    Keywords : Cancer immunotherapy; brain cancer; neoantigen; MHC HLA; TCR;

    Abstract : Background Cancer immunotherapy has yielded many successes. Yet to some hard-to-treat brain tumors, such as glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), it still lacks substantial improvement. Neoantigens resulting from mutations in malignant cells are the key targets for employing adoptive cell therapies. READ MORE

  2. 2. System level analysis of Immune system in children with solid tumors

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Science for Life Laboratory, SciLifeLab

    Author : Nadia Hassan Shamas; [2022]
    Keywords : Immune system in Children; Cancer; Medicines;

    Abstract : Over the last few years, significant immune system changes have been observed in tumor patients exposed to different treatments. Moreover, evaluation and prediction of the responses of treatments given to these patients can become a key component. READ MORE

  3. 3. Filtering of Clinical NGS Data to Improve Low Allele Frequency Variant Calling

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Tomas Cumlin; [2022]
    Keywords : Next-generation sequencing; Variant calling; Clinical sequencing; Substitution error; Cancer sequencing; Error rate; substitution; Somatic mutation;

    Abstract : Massive parallel sequencing (NGS) is useful in detecting and later classifying somatic driver mutations in cancer tumours. False-positive variants occur in the NGS workflow and they may be mistaken for low frequency somatic cancer mutations in a patient sample. READ MORE

  4. 4. Affibody phage display selections for lipid nanoparticle and affibody-mediated transient CAR T-cell therapy

    University essay from KTH/Proteinvetenskap

    Author : Tasnim Yasin Idris; [2022]
    Keywords : affibody; phage display; in vitro selection; CD5; CD8; CD19; CAR T-cell therapy.;

    Abstract : CAR T-cellbehandling är en immunterapi som har visat lovande resultat vid behandling av cancer. Trots det riktade immunsvaret som kan uppnås, betonar komplexiteten i tillverkningsprocessen och behandlingsproceduren det utrymme somm finns för förbättringar. READ MORE

  5. 5. Effect of doxorubicin exposure in breast cancer on single-cell level by scRNA-seq analysis

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Núria Lladós Armengol; [2021]
    Keywords : ;

    Abstract : Doxorubicin is a highly effective chemotherapeutic agent against a variety of cancers; however, the exact mechanisms responsible for the effects of doxorubicin on cancer are not widely understood and have not been studied on a single-cell level. Single-cell RNA sequencing analysis is a recent technology that enables the assessment of transcriptional similarities and differences within a population of cells. READ MORE