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Showing result 1 - 5 of 57 essays matching the above criteria.

  1. 1. Regulatory Driven Clustering of Single-Cell Data; Clustering of single-cell RNA sequencing from glioblastoma with a novel mathematical method

    University essay from Göteborgs universitet/Institutionen för matematiska vetenskaper

    Author : Kári Kristjánsson; [2023-08-08]
    Keywords : ;

    Abstract : Cancer is a leading cause of death worldwide. Single-cell RNA sequencing has arisen as an important method to explore the gene expression of biological cells, including cancer cells. In this study, we deployed a computational algorithm known as ScRegClust to dissect single-cell RNA-sequencing (scRNA-seq) data from brain tumors. READ MORE

  3. 2. Methodological development of human telomere sequencing with the Oxford Nanopore Technologies

    University essay from Örebro universitet/Institutionen för hälsovetenskaper

    Author : Jennifer Arnqvist; [2023]
    Keywords : ;

    Abstract : Human DNA is protected with telomeres, which consist of the repetitive DNA-sequence TTAGGG. A 3’-overhang folds back and in combination with the shelterin complex protects the ends of the DNA. READ MORE

  4. 3. CRISPR Screen to Identify Genes Regulating Melanoma Cell Invasiveness

    University essay from KTH/Proteinvetenskap

    Author : Emma Kroon; [2023]
    Keywords : CRISPR-Cas9; gene knockout; viral packaging; transduction; invasionstest; CRISPR-Cas9; genknockout; viruspackning; transduction; invasion assay;

    Abstract : Maligna cancerceller har förmågan att sprida sig okontrollerat i kroppen och metastasera till avlägsna organ. Kritiskt i metastaserings processen är cancercellers förmåga att invadera närliggande vävnader innan de sprider sig vidare ut i kroppen. READ MORE

  5. 4. Gene expression editing in myeloma cell lines using CRISPR/Cas9 technique

    University essay from Uppsala universitet/Institutionen för medicinsk cellbiologi

    Author : Wilma Wadman; [2023]
    Keywords : BMPR1A; BMPR2; bone morphogenetic protein; gene knockout; multiple myeloma;

    Abstract : Multiple myeloma, or myeloma, is a bone marrow cancer which characterizes by uncontrolled proliferation of mutant plasma cells. It is a disease that claims many lives every year, mostly due to the absence of curative treatment. Finding a suitable treatment is therefor of great importance. READ MORE

  6. 5. Ovary spheroid formation and quality assessment using two different protocols

    University essay from KTH/Proteinvetenskap

    Author : Nikki Wallius Hiltunen; [2023]
    Keywords : ovary; fertility; spheroid; Biosilk™; three-layer gradient system; äggstock; fertilitet; sfäroid; Biosilk™; trelagers gradientsystem;

    Abstract : Redan innan födseln fastställs kvinnors fertilitet, som karakteriseras av ett begränsat antal äggblåsor, så kallade folliklar. Beståndet av folliklar minskar naturligt med åldern, samtidigt som kvinnors fertilitet beror på deras steroid- och äggproduktion. READ MORE