Essays about: "Cancer sequencing"

Showing result 11 - 15 of 57 essays containing the words Cancer sequencing.

  1. 11. Molecular mapping of the HGSOC tumour microenvironment

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Philippine Louail; [2023]
    Keywords : Immunology; Ovarian cancer; Multiplex Immunofluorescence; scRNA sequencing; Bioinformatics; Image analysis;

    Abstract : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. READ MORE

  3. 12. Improving Usability of Bioinformatics Software with an Integrated Web Tool System for Cancer Diagnostics

    University essay from KTH/Skolan för elektroteknik och datavetenskap (EECS)

    Author : Solbritt Gateman; [2023]
    Keywords : Web development; bioinformatics pipelines; precision medicine; user-centred design; interface design;

    Abstract : Precision cancer medicine is an area of research that involves complex bioinformatics software for the clinical analysis pipelines that sequencing data is passed through. A research team at Karolinska Institutet (KI) is running clinical trials to test new methods of precision cancer medicine and is working on creating a new web application that will be integrated with their two existing applications to aid bioinformaticians in their work of running pipelines and producing clinical reports for the hospitals. READ MORE

  4. 13. Identification of Immunological Targets for Brain Cancer Immunotherapy

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Zhenda Wang; [2022]
    Keywords : Cancer immunotherapy; brain cancer; neoantigen; MHC HLA; TCR;

    Abstract : Background Cancer immunotherapy has yielded many successes. Yet to some hard-to-treat brain tumors, such as glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG), it still lacks substantial improvement. Neoantigens resulting from mutations in malignant cells are the key targets for employing adoptive cell therapies. READ MORE

  5. 14. Evaluation and implementation of quality control parameters for genome-wide DNA methylome sequencing

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Sara Ekberg; [2022]
    Keywords : ;

    Abstract : Epigenomics is the study of modifications to the genetic material without changes to the DNA sequence, one such modification is methylation of nucleotides. DNA methylation is associated with gene regulation and is studied in a variety of fields such as cancer and ageing. READ MORE

  6. 15. Investigation of Chromatin Organization and mRNA Expression in Drug Treated Human Erythroleukemia Cells

    University essay from KTH/Proteinvetenskap

    Author : Anam Minhas; [2022]
    Keywords : Erythroleukemia cells; mRNA-seq; ATAC-seq; Doxorubicin; Vinblastine; Erytroleukemiceller; mRNA-expression; kromatin; Doxorubicin; Vinblastine;

    Abstract : Syftet med detta projekt var att undersöka hur vanligt använda cancerläkemedel påverkar mRNA-uttryck och kromatinorganisation i humana erytroleukemiceller. Som modell användes K562-celler från en patient i blastocystkris (2), för att utvärdera leukemicellernas svar på cancerläkemedel vinblastin och doxorubicin. READ MORE