Essays about: "Carbapenem resistance"

Showing result 1 - 5 of 8 essays containing the words Carbapenem resistance.

  1. 1. The Binding Mechanism of Carbapenems in the Class A beta-lactamase IMI-1 : A Molecular Dynamics Study of Ligand Stability

    University essay from Uppsala universitet/Biokemi

    Author : Isabell Lindahl; [2022]
    Keywords : antibiotic resistance; IMI-1; betalactamase; Carbapenemase; free energy; LIE; linear interaction energy; β-lactamase; meropenem; biapenem; imipenem; active site;

    Abstract : Antibiotic resistance is a global and accelerating matter. Over time, the bacteria have evolved several defense mechanisms against the antibiotics. One of the defense mechanisms is that the bacteria can produce enzymes with the ability to hydrolyze the characteristic b-lactam ring of the antibiotics. These enzymes are called b-lactamases. READ MORE

  3. 2. Screening for carbapenemase-associated biomarkers in Klebsiella oxytoca using matrixassisted laser desorption/ionization time of flight mass spectrom

    University essay from Örebro universitet/Institutionen för naturvetenskap och teknik

    Author : Hannah Uppström; [2022]
    Keywords : MALDI-TOF MS; carbapenems; Verona integron-encoded metallo-β-lactamase; carbapenem resistance; AST biomarkers;

    Abstract : Antibiotic resistant bacteria are threatening human health, and the resistance is progressingfaster than the development of new antimicrobial compounds. Antibiotic resistant infections cost enormous sums of money and resources, but most importantly human lives. READ MORE

  4. 3. Antibiotic combination therapies against carbapenamse producing Klebsiella pneumoniae

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Thomas Söderhäll; [2021]
    Keywords : Klebsiella pneumoniae; carbapenem resistance; carbapenemase; combination therapy; meropenem; colistin; avibactam; constucts; porins;

    Abstract : The treatment options for multidrug resistant bacteria are dwindling and it is an important issue of research in medicine to solve. One of the more problematic bacterial species is Klebsiella pneumoniae, it can cause infections with high morbidity that are difficult to treat. READ MORE

  5. 4. Multi-drug resistant Gram-negative bacteria in wastewater treatment plants : -With focus on Acinetobacter baumannii complex

    University essay from Örebro universitet/Institutionen för naturvetenskap och teknik

    Author : Joanna Eaton; [2020]
    Keywords : ;

    Abstract : Multidrug-resistant (MDR) pathogens are emerging problems humanity faces today. Increasing MDR Gram-negative bacteria is not only a threat towards humanity itself but also towards food safety. The genus Acinetobacter is an environmental bacterium that can be found in habitats, including aquatic environments, soil, wastewater, food, and animals. READ MORE

  6. 5. Screening for double carbapenem therapies effective against multidrug resistant Enterobacteriaceae

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Karin Vickberg; [2019]
    Keywords : Combination therapy; Carbapenem resistance; Carbapenemase; Carbapenem-resistant Enterobacteriaceae CRE ; Carbapenemase-producing Enterobacteriaceae; Klebsiella pneumoniae carbapenemase KPC ; New Delhi metallo-b-lactamase NDM ; Oxacillinase OXA ; Ertapenem ETP ; Doripenem DOR ; Meropenem MEM ; Broth microdilution BMD ; Time-lapse microscopy oCelloScope ; Time-kill experiments; Synergy;

    Abstract : Multidrug resistant bacteria account for one of the biggest threats to human health in the future. One treatment option to be evaluated is antibiotic combination therapy. For this purpose, last- line carbapenems have been suggested, even when bacteria are resistant, e.g. READ MORE