Essays about: "Chronic Myeloid Leukemia"

Found 5 essays containing the words Chronic Myeloid Leukemia.

1. 1. Validation and optimization of multiplexInSitu PLA for signalling pathway analysis

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Tanay Kumar Sinha; [2021]
   Keywords : Chronic myeloid leukemia Tyrosine kinase inhibitors Proximity ligation assay Cross-reactivity Padlock Template;

   Abstract : With the advent of Tyrosine kinase inhibitors (TKI) as a therapy for Chronic myeloid Leukemia (CML), the patients now enjoy a life expectancy close to that of the general population. But some patients do get unresponsive to the TKI treatment over time due to several mutations in the kinase domain of the BCR-ABL fusion protein, which further leads to activation of multiple signaling cascades within the leukemic cell, helping it survive and proliferate. READ MORE

3. 2. BCR-ABL1A TYROSINE KINASE ASSOCIATED WITH CHRONIC MYELOID LEUKEMIA : Calculation of solvation energiesand electrostatics by APBS and prediction of 2D and 3D structureby homology protein modeling

   University essay from Umeå universitet/Institutionen för integrativ medicinsk biologi (IMB)

   Author : Anna Tiltu Klintborg; [2021]
   Keywords : ;

   Abstract : .... READ MORE

4. 3. Feeling the zeros : Modeling individual responses, measured against time, to treatment of chronic myeloid leukemia.

   University essay from Uppsala universitet/Statistiska institutionen

   Author : Anna Warnqvist; [2017]
   Keywords : two-level modeling; censored modeling; chronic myeloid leukemia;

   Abstract : In this paper response curves of patients with chronic myeloid leukemia are modeled using one and two-level censored models. Two-level models (also called mixed models) allow random effects and censored models are used to account for the large amount of values too small to be detected. READ MORE

5. 4. Prognostic Factors for 12 Month Major Molecular Response for Patients with Chronic Myeloid Leukemia

   University essay from Statistiska institutionen

   Author : Jonas Höijer; [2013]
   Keywords : Chronic Myeloid Leukemia; CML; Major Molecular Response; MMR; Prognostic factors; Logistic regression; Statistical modelling;

   Abstract : Chronic Myeloid Leukemia is a kind of blood cancer with around 1 incidence per 100 000 persons/year. After the development of an effective treatment, imatinib, in the late 1990:s, the survival percentage has increased drastically. READ MORE

6. 5. Development of a quantitative chromatographic method for the determination of Imatinib and its main metabolite in human plasma

   University essay from Institutionen för fysik, kemi och biologi

   Author : Paulina Hillberg; [2009]
   Keywords : Imatinib; HPLC-UV; LC-MS; analytical chemistry; CML;

   Abstract : The objective of this master thesis was to develop an analytical method for the quantification of the cancer drug Imatinib and its main metabolite CGP74588 in plasma. Imatinib is used in the treatment of chronic myeloid leukemia and gastrointestinal stroma tumors. READ MORE