Essays about: "Continuous chromatography"

Showing result 1 - 5 of 14 essays containing the words Continuous chromatography.

1. 1. Screening of HETP test conditions and resin storage solutions for HIC

   University essay from Uppsala universitet/Analytisk farmaceutisk kemi

   Author : Lise-Lotte Ronnerfors; [2023]
   Keywords : Hydrophobic Interaction Chromatography; Pfizer Health AB; Column packing;

   Abstract : Hydrophobic interaction chromatography (HIC) is a common purification method for biological drug substances. For continuous monitoring the quality of the purification, a column performance test is carried out to test the packing of the resin. READ MORE

3. 2. Advanced control of chromatography systems for automated analysis of monoclonal antibodies

   University essay from Lunds universitet/Kemiteknik (CI)

   Author : Jerry Guan; [2021]
   Keywords : Chemical engineering; Kemiteknik; Chromatography; Analysis; HPLC; Python; Automatic process control; Monoclonal Antibodies; Antibody purification; Technology and Engineering;

   Abstract : Nedströmsprocesser för rening av biologiska läkemedel som monoklona antikroppar rör sig från batch-processer till kontinuerliga, och vidare till helt automatiska, kontinuerliga nedströmsprocsser. En del av visionen för automatiska reningsprocesser är möjligheten att automatiskt analysera från olika steg av reningen. READ MORE

4. 3. Design and Analysis of Continuous Virus Inactivation Reactors in Biopharmaceutical Production

   University essay from Lunds universitet/Kemiteknik (CI)

   Author : Hanna Danielsen; [2020]
   Keywords : Chemical engineering; Kemiteknik; Virus inactivation; Chromatography; Technology and Engineering;

   Abstract : The biopharmaceutical industry is replacing the current batch process with a continuous one and an essential step in the downstream process is the virus inactivation (VI). The challenge with a continuous VI reactor is to generate a narrow residence time distribution (RTD), while ensuring a precise incubation time. READ MORE

5. 4. Identification of metabolite-protein interactions among enzymes of the Calvin Cycle in a CO2-fixing bacterium

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Emil Sporre; [2020]
   Keywords : Cupriavidus necator; chemolithoautotroph; limited proteolysis; Calvin Cycle; carbon fixation; proteomics; allosteric regulation; metabolite-protein interactions.;

   Abstract : The Calvin – Benson cycle is the most widespread metabolic pathway capable of fixing CO2 in nature and a target of very high interest to metabolic engineers worldwide. In this study, 12 metabolites (ATP, AMP, NADP, NADPH, 2PG, 3PGA, FBP, RuBP, PEP, AKG, Ac-CoA and phenylalanine) were tested for protein – metabolite interactions against the proteome of Cupriavidus necator (previously Ralstonia eutropha) in the hopes of finding potential examples of allosteric regulation of the Calvin – Benson cycle. READ MORE

6. 5. Towards autonomous antibody purification

   University essay from Lunds universitet/Kemiteknik (CI)

   Author : Frida Heskebeck; [2019]
   Keywords : Chemical engineering; Kemiteknik; Simulation; Chromatography; Periodic counter-current chromatography; Python; PCC; Technology and Engineering;

   Abstract : The vision of antibody purification is to have the whole process fully automatic. It is often desirable to have a continuous process since that reduces the costs for production and the size of the used equipment. It is necessary to supply buffer solutions to the purification steps, and as part of the vision; this should be done automatically. READ MORE