Essays about: "Cross-reactivity"

Showing result 1 - 5 of 11 essays containing the word Cross-reactivity.

1. 1. Immunological Cross-Reactivity : Construction of a Workflow That Enables Cross-Reactivity Predictions

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Alexander Blomlöf; Alvin Unge; Petter Byström; Erika Lindberg; Torbjörn Fries; [2022]
   Keywords : Cross- reactivity; Immunology; Epitope; Paratope; Antibody; Prediction; Substitution analysis; Proximity Extension Assay; Bioinformatic tools;

   Abstract : Cross-reactivity occurs when an antibody binds to the epitope of a protein that is not the targeted antigen. This is problematic in the analysis of immunoassay diagnostics. Detecting a protein incorrectly might cause issues such as incorrect mapping of metabolic conditions for research or diagnosis. READ MORE

3. 2. Validation of anti-cytokeratin antibodies used in rapid cancer diagnostics by isoelectric focusing and QCM technology

   University essay from Uppsala universitet/Biokemi

   Author : Reneh Kostines; [2021]
   Keywords : IEF; Isoelectric focusing; QCM; Attana; Cytokeratin; Keratin; Attana; Anti-cytokeratin; cancer; UBC; IDL; epithelial carcinomas; Antibody validation; Biosensor; Biosensors;

   Abstract : Antibodies are Y-shaped proteins. In the human body, antibodies areproduced by plasma cells, mainly T and B cells which are included inthe adaptive immune system. The production of antibodies is stimulatedby antigens. The binding between an antigen-specific antibody and itsantigen can be like the interconnect between a lock and a key. READ MORE

4. 3. Validation and optimization of multiplexInSitu PLA for signalling pathway analysis

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Tanay Kumar Sinha; [2021]
   Keywords : Chronic myeloid leukemia Tyrosine kinase inhibitors Proximity ligation assay Cross-reactivity Padlock Template;

   Abstract : With the advent of Tyrosine kinase inhibitors (TKI) as a therapy for Chronic myeloid Leukemia (CML), the patients now enjoy a life expectancy close to that of the general population. But some patients do get unresponsive to the TKI treatment over time due to several mutations in the kinase domain of the BCR-ABL fusion protein, which further leads to activation of multiple signaling cascades within the leukemic cell, helping it survive and proliferate. READ MORE

5. 4. Evaluation of an equine-optimized enzyme-linked immunosorbent assay for the determination of serum insulin in canine and feline samples

   University essay from Uppsala universitet/Institutionen för kvinnors och barns hälsa

   Author : Ylva Moberg; [2018]
   Keywords : Cross-reactivity; hypoglycaemia; immunoassay; insulinoma; validation;

   Abstract : Background: Insulin is an important hormone for glucose homeostasis. It is released from β-cells in the endocrine pancreas as a response to increased concentrations of plasma glucose. The major effect of insulin is the facilitation of cellular uptake and storage of glucose as glycogen. READ MORE

6. 5. Schmallenberg virus among ruminants in the Gaza province, Mozambique

   University essay from SLU/Dept. of Biomedical Sciences and Veterinary Public Health

   Author : Maria Rystedt; [2017]
   Keywords : Schmallenberg virus; Simbu serogroup; ruminants; arbovirus; seroprevalence; cross reactivity; PCR; Mozambique; idisslare; seroprevalens; korsreaktion;

   Abstract : Schmallenberg virus was discovered in North Rhine-Westphalia in Germany in 2011. The virus spread over most of Europe during the following years, including United Kingdom and the Nordic countries. Its origins are yet to be discovered. Schmallenberg virus belongs to the Simbu serogroup of the Bunyaviridae family, genus Orthobunyavirus. READ MORE