Essays about: "Cysteine residues"

Showing result 1 - 5 of 9 essays containing the words Cysteine residues.

  1. 1. Production and analysis of novel disulfide variants of Subtilisin Carlsberg

    University essay from Linköpings universitet/Kemi

    Author : Anton Elfstrand; [2023]
    Keywords : Subtilisin Carlsberg; Disulfide; Protein Engineering; Kinetic Stability;

    Abstract : Protein engineering has been used to alter the stability of proteins for several decades withmuch success, one approach being to introduce two cysteine residues that together form adisulfide bridge. The disulfide bridge can increase the Gibbs free energy of the transitionstate, thus increasing energy difference between the folded state and the unfolding transitionstate, leading to increased kinetic stability of the protein. READ MORE

  3. 2. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator

    University essay from Uppsala universitet/Institutionen för kemi - BMC

    Author : Carita Hammar; [2022]
    Keywords : ;

    Abstract : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. READ MORE

  4. 3. Bri2 BRICHOS domain : Eukaryotic expression and importance of strictly conserved cysteine residues

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Lovisa Hemmingsson; [2017]
    Keywords : Bri2 BRICHOS; Aß; Chaperone; Amyloid fibril formation; Alzheimer disease; Eukaryotic expression; Cysteine residues;

    Abstract : Alzheimer’s disease (AD), the most common form of dementia is associated with fibril formation of amyloid-ß peptides (Aß). Aß, proteolytically derived from Aß precursor protein (AßPP), is the major component of amyloid plaques in AD brains. READ MORE

  5. 4. Enzymatic cleavage of HMGB1

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Merlin Rensing; [2017]
    Keywords : HMGB1; enzymatic cleavage; neutrophil Elastase; cathepsin G; matrix metalloproteinase-3; arthritis;

    Abstract : Alarmins and damage associated molecular pattern (DAMP) are endogenous proteins with distinct and various intracellular roles that when released extracellularly act as startingsignals for inflammatory immune responses. The endogenous protein High mobility group box 1 (HMGB1) acts as a DAMP and has been shown to drive progression of multiple inflammatory and autoimmune diseases. READ MORE

  6. 5. Characterization of Protein Surface Interactions : Collagen and Osteocalcin

    University essay from Institutionen för fysik, kemi och biologi; Tekniska högskolan

    Author : Patrik Johansson; [2013]
    Keywords : Osteocalcin; Collagen; SFG; ToF-SIMS; XPS; AFM; Orientation; Surface;

    Abstract : This work investigates how the proteins collagen type I and human osteocalcin interact with various surfaces. A pH-series of collagen adsorbed onto methyl terminated self-assembled monolayers has been made and the results indicate that less tropocollagen is found on the surfaces at pH below 6. READ MORE