Essays about: "Dose-response models"

Showing result 1 - 5 of 7 essays containing the words Dose-response models.

  1. 1. Design and analysis of pre-clinical experiments using a method combining multiple comparisons and modeling techniques for dose-response studies

    University essay from Göteborgs universitet/Institutionen för matematiska vetenskaper

    Author : Avijit Singh; [2021-04-20]
    Keywords : pharmacodynamic modeling; dose–response relationship; significance level; multiple comparison procedure; optimal design; MCPMod; dose finding study;

    Abstract : Abstract. Identifying and estimating the dose-response relationship between a compound and a pharmacological endpoint of interest is one of the most important and difficult goals in the preclinical stage of pharmaceutical drug development. READ MORE

  3. 2. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    University essay from Lunds universitet/Institutionen för immunteknologi

    Author : Kajsa Andreasson Dahlgren; [2021]
    Keywords : Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Abstract : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. READ MORE

  4. 3. Comparison of Multiple Models for Diabetes Using Model Averaging

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Alex Al-Mashat; [2021]
    Keywords : pharmacometrics; population pharmacokinetics; pop-pk; pop-PK diabetes; model averaging; MA; cross-validation; cv; CV; akaike information criterion; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c; farmakometri; populationsfarmakokinetik; diabetes; model averaging; MA; cross-validation; cv; CV; akaike; Akaike; aic; AIC; MPG; mpg; FPG; fpg; FPI; fpi; HbA1c; hba1c;

    Abstract : Pharmacometrics is widely used in drug development. Models are developed to describe pharmacological measurements with data gathered from a clinical trial. The information can then be applied to, for instance, safely establish dose-response relationships of a substance. READ MORE

  5. 4. Active dose selection and dose-response modeling for quantitative high-throughput screening (qHTS)

    University essay from Uppsala universitet/Cancerfarmakologi och beräkningsmedicin

    Author : Joel Ås; [2016]
    Keywords : ;

    Abstract : This master thesis studies the potential benefit of iterative selection of the concentrations evaluated when building mathematical dose-response curves (and response surfaces when there are two drugs) using experimental measurements. The reference alternative is to use a standard two-fold dilution series or ten-fold dilution series measured in replicates. READ MORE

  6. 5. Robust Optimization for Uncertain Radiobiological Parameters in Inverse Dose Planning

    University essay from KTH/Optimeringslära och systemteori

    Author : Jennie Falk; [2015]
    Keywords : ;

    Abstract : Cancer is a common cause of death worldwide with radiotherapy as one of the most used treatments. Radiation treatment plans are normally optimized using constraints on the maximum dose to tumours and minimum dose to surrounding healthy structures. READ MORE