Essays about: "Dose-response"

Showing result 1 - 5 of 56 essays containing the word Dose-response.

  1. 1. Apoptosis induction in breast cancer cells after radiotherapy and potential radiosensitizers

    University essay from

    Author : Klara Simonsson; [2023-06-27]
    Keywords : Medical physics; Breast cancer cells; radiotherapy; systemic therapy; combination therapy; apoptosis; BH3 profiling; flow cytometry;

    Abstract : Background. Today breast cancer is the foremost cancer death type amongst women around the world. At present some of the toughest challenges in the clinic is recurrent, radioresistant breast cancer, and metastatic breast cancer where low cure rates are observed after surgery and radiotherapy. READ MORE

  3. 2. Characterization of diazepam binding inhibitor as a structure-function tool for human ɣ-aminobutyric acid-A receptors

    University essay from KTH/Proteinvetenskap

    Author : Szabolcs Simon-Guth; [2023]
    Keywords : γ-Aminobutyric acid sub-type A receptors; diazepam binding inhibitor; receptor modulation; recombinant protein expression; two-electrode voltage clamp; dose-response curve; Gammaaminosmörsyrareceptor typ A; Diazepambindande hämmare; receptormodulering; reckmbinant proteinexpression; spänningsklämma med två elektroder; dosresponskurva;

    Abstract : Gammaaminosmörsyrareceptorer typ A (GABAAR) är pentameriska ligandstyrda kloridkanaler som uppvisar neurohämmande egenskaper. Därmed är de primära läkemedelsmål för flera ångestdämpande och lugnande läkemedel som används för att minska förekomsten av aktionspotential i neuroner. READ MORE

  4. 3. Polymer gel dosimetry with MRI-readout for 3D dose verification - detector characteristics and clinical applications

    University essay from Lunds universitet/Sjukhusfysikerutbildningen

    Author : Thi Guldhill; [2023]
    Keywords : Medicine and Health Sciences;

    Abstract : Background & Purpose: Radiation therapy is an essential treatment for cancer patients with the ultimate goal to deliver radiation doses to the tumour with precision while minimizing exposure to surrounding healthy tissues. Treatment verification is crucial to ensure the accuracy of radiation delivery, for instance by measuring the radiation dose distribution. READ MORE

  5. 4. Compounds screening for the identification of novel drug to improve the Knock in efficiency mediated by CRISPR-Cas9

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Evangelia Anagnostou; [2023]
    Keywords : Genome editing; Knock in; HDR; CRISPR-Cas9; screening; NHEJ;

    Abstract : Genome editing is an exciting field that allows for the precise modification of an organism's DNA. One of the most advanced tools in this area is CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9), which creates a DSB (Double-strand break) at a specific location in the genome. READ MORE

  6. 5. CHARACTERIZATION AND EVALUATION OF A NIPAM POLYMER GEL MRI DOSIMETER SYSTEM

    University essay from

    Author : Christian Waldenberg; [2022-11-08]
    Keywords : Medical physics; Normoxic polymer gel dosimeter; NiPAM;

    Abstract : Purpose: The normoxic polymer gel dosimeter based on N-isopropyl acrylamide (NiPAM) is a promising full 3D-dosimeter with high spatial resolution and near tissue equivalency. However, limited work have been done in vestigating this dosimeter. The dose response and reproducibility of a NiPAM dosimeter was investigated. READ MORE