Essays about: "ERK"

Showing result 1 - 5 of 9 essays containing the word ERK.

1. 1. Ligand-stimulated cleavage of PDGFR-beta

   University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

   Author : Agni Karolina Tsiatsiou; [2023]
   Keywords : ;

   Abstract : Platelet-derived growth factor receptors (α and β) are included in the family of receptor tyrosine kinases (RTKs). The dimeric PDGF ligands bind to the PDGF receptors and this results in receptor dimerization, autophosphorylation, and thus activation. The autophosphorylated receptor dimer activates numerous signaling pathways. READ MORE

3. 2. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

   University essay from Lunds universitet/Institutionen för immunteknologi

   Author : Kajsa Andreasson Dahlgren; [2021]
   Keywords : Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

   Abstract : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. READ MORE

4. 3. The effects of NOX2 and NOX4 inhibitors on panc-1 cell viability

   University essay from Högskolan i Skövde/Institutionen för hälsovetenskaper

   Author : Karl-Hermann Sielinou Kamgang; [2020]
   Keywords : ;

   Abstract : Pancreatic cancer is a leading cause of cancer related deaths worldwide and has a low survival rate 1 year after diagnosis. It is therfore important to identify new biomarkers and treatments to improve disease outcome. This experiment investigated the effects of different NOX2 and NOX4 inhibitors on Panc-1 cell lines. READ MORE

5. 4. Characterization of pERK expression in amygdala and its role in nociceptive behavior

   University essay from SLU/Dept. of Microbiology

   Author : Mychelly Moraes De Siqueira; [2016]
   Keywords : amygdala; extracellular signal-regulated kinase ERK ; mitogen-activated protein kinase MAPK ; nociceptive; pain;

   Abstract : Extracellular signal-regulated kinase (ERK), is a member of the mitogen-activated protein kinase (MAPK) family of serine/threonine protein kinases. Functioning as intracellular signaling molecules, they are responsible for multiple extracellular signals transduction into diverse intracellular responses through transcriptional and post-translational regulations. READ MORE

6. 5. Knockdown of the ERK pathway using siRNA in cultured chicken cardiomyocytes

   University essay from Biologi; Tekniska högskolan

   Author : Caroline Ovrén; [2014]
   Keywords : cell culture; RNA interference; cardiomyocytes; ERK; MAPK;

   Abstract : The ancient South American birds called tinamous (Tinamidae) have the smallest hearts known among birds and their cardiomyocytes have previously been shown to express significantly lower levels of the mitogen-activated protein kinase ERK compared to the more modern chicken (Gallus gallus). ERK is a well-known mediator of growth signalling in the heart, especially in hypertrophy. READ MORE