Essays about: "Farmaci"

Showing result 1 - 5 of 68 essays containing the word Farmaci.

  1. 1. Development of ultra-sensitive immunoassay on Gyrolab microfluidic platform using Binding Oligo Ladder Detection : Enhancing Gyrolab biomarker assays using Exazym®

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Sam Vadi Dris; [2024]
    Keywords : Immnoassay; Gyrolab; TNF-alpha; Ultra-sensitive; Cavidi; Exazym; BOLD amplification; Amplification;

    Abstract : Immunoassays are widely used for detection of antigens in a wide range of applications including assays in pharmaceutical development. Immunoassays are continuously improved in many aspects including automatization, miniaturization and extending the dynamic range. READ MORE

  3. 2. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Johan Borg; [2023]
    Keywords : pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

    Abstract : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. READ MORE

  4. 3. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Jonathan Efverström; [2023]
    Keywords : Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Abstract : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. READ MORE

  5. 4. Increased system sensitivity using fluorescent based immunoassays on the Gyrolab® platform

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Gabriel Lisra; [2023]
    Keywords : Gyrolab; fluorescence; sensitivity; immunoassays;

    Abstract : Immunoassays have become an essential tool in several fields of bioanalytics with tremendous advances in sensitivity and formats seen through the last three decades. Many diseases are today diagnosed solely based on biomarker concentrations evaluated through immunoassays. READ MORE

  6. 5. Time-varying biomarkers modelling for potential prediction of long-term complications and mortality in patients with type 2 diabetes

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Chengli Yu; [2023]
    Keywords : ;

    Abstract : .... READ MORE