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Showing result 1 - 5 of 27 essays matching the above criteria.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    University essay from Uppsala universitet/Analytisk kemi

    Author : Maryam Dost; [2024]
    Keywords : Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Abstract : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. READ MORE

  3. 2. Implementation of a Conceptual Computational Model to estimate the Delay Time in Drug Delivery to reduce Medication Errors in Pediatric Emergency Care

    University essay from KTH/Medicinteknik och hälsosystem

    Author : Maja Sandén; [2023]
    Keywords : Intravenous Infusion Pump; Compartmental Modeling; Pediatric.; Intravenös Infusions Pump; Beräkningsmodell; Pediatrik;

    Abstract : Infusion pumps are used in all departments of a hospital, in the emergency care unit as well as in pediatrics. The pumps administer intravenous medications for the purpose of helping patients to manage pain and are unfortunately not spared from emerging errors. READ MORE

  4. 3. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study

    University essay from KTH/Medicinteknik och hälsosystem

    Author : Simon Jenner; Dennis Amphan; [2020]
    Keywords : Pharmacology; Pharmacokinetics; Pharmacodynamics; PKPD-model; Diabetes; Adherence; Modelling; Feasibility; Farmakologi; Farmakokinetic; Farmakodynamik; PKPD-model; Diabetes; ̊Atlydnad; Modellering; Genomf ̈orbarhet;

    Abstract : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. READ MORE

  5. 4. External validation of a tool to assess medication-related admissions in four Swedish hospitals

    University essay from Uppsala universitet/Avdelningen för farmakokinetik och läkemedelsterapi

    Author : Filip Nacke; [2019]
    Keywords : ;

    Abstract : External validation of a tool to assess medication-related admissions in four Swedish hospitals Background The MedBridge trial is a large ongoing clinical trial on medication reviews in elderly patients in Sweden with participating hospitals from Uppsala, Enköping, Västerås and Gävle. A tool for assessing medication-related admissions (MRAs) has been developed and validated in Uppsala: Assessment Tool for identifying Hospital Admissions Related to Medications (AT-HARM10). READ MORE

  6. 5. Biotillgänglighet för buprenorfin efter subkutan administrering till kanin

    University essay from SLU/Dept. of Clinical Sciences

    Author : Elin Fredriksson; [2019]
    Keywords : kanin; buprenorfin; smärtlindring; analgesi; subkutan; intravenös; biotillgänglighet; farmakokinetik;

    Abstract : Kaniner är både populära sällskapsdjur och används ofta experimentellt inom forskning. Kaniner kan behöva genomgå kirurgiska ingrepp och effektiv postoperativ smärtlindring är nödvändig för att upprätthålla god djurvälfärd. READ MORE