Essays about: "GPCRs"

Showing result 1 - 5 of 11 essays containing the word GPCRs.

  1. 1. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Micaela Andersson; [2022]
    Keywords : Deorphanization; Heterodimerization; High-throughput screening; Orphan G-protein Coupled receptor; Pseudogenes; Reversed pharmacology;

    Abstract : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. READ MORE

  3. 2. The differential signalling of the succinate receptor SUCNR1/GPR91, through Gi versus Gq

    University essay from Lunds universitet/Teknisk mikrobiologi

    Author : Sofie Liljewall; [2022]
    Keywords : GPR91; SUCNR1; G protein recruitment; Gi; Gq; TRUPATH biosensor; BRET2; Applied Microbiology; Biology and Life Sciences;

    Abstract : G protein-coupled receptors are the biggest family of membrane bound receptor in the human genome, they are also target for many drugs due to their accessible location in the cell membrane. We have characterized the G protein recruitment of the succinate receptor 1 (SUCNR1/GPR91). READ MORE

  4. 3. Challenging specificity of chemicalcompounds targeting GPCRs with cellprofiling

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Anton Davidsson; [2020]
    Keywords : cell profiling; gpcr; g-protein coupled receptor;

    Abstract : Screening compounds with image-based analysis is an important part in the processof drug discovery. It is an efficient way to screen compounds as it gives moreinformation than for example HTS. READ MORE

  5. 4. Computational Methods for the structural and dynamical understanding of GPCR-RAMP interactions

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Silvia Bahena; [2020]
    Keywords : Protein-protein interaction; coarse-grained; G protein-coupled receptors; receptor activity–modifying proteins;

    Abstract : Protein-protein interaction dominates all major biology processes in living cells. Recent studies suggestthat the surface expression and activity of G protein-coupled receptors (GPCRs), which are the largestfamily of receptors in human cells, can be modulated by receptor activity–modifying proteins (RAMPs). READ MORE

  6. 5. Probing the G protein selectivity of FR900359 by means of molecular modeling and site directed mutagenesis

    University essay from Umeå universitet/Farmakologi

    Author : Michelle Malmberg; [2017]
    Keywords : GPCRs; G protein; FR900359; YM-254890; Molecular modeling;

    Abstract : .... READ MORE