Essays about: "GRN"

Showing result 1 - 5 of 7 essays containing the word GRN.

  1. 1. Inferring Gene regulatory networks using Graph Neural Networks

    University essay from KTH/Genteknologi

    Author : Sohta Makino; [2023]
    Keywords : Graph Attention Network; Gene regulatory Network; Transcription; Data Science; Machine learning; Genreglering; transkription; dataanalys; Inferens; maskininlärning;

    Abstract : Inom beräkningsbiologin är det snabbt på väg att bli allt vanligare att ta fram genetiska regleringsnätverk (GRN). På grund av storleken på de undersökta nätverken använder många forskare maskininlärning för att härleda GRN från genuttrycksdata, vanligtvis från RNA-seq. READ MORE

  3. 2. Energy Landscapes for Early T Cell Development

    University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Yukun Cheng; [2022]
    Keywords : Physics and Astronomy;

    Abstract : T cell lineage development from an early thymic progenitor involves programmed shutoff of progenitor gene expression, upregulation of T cell specification genes, and proliferation. This biological system has been deeply studied and a gene regulatory network (GRN) that can accurately describe the system has been presented. READ MORE

  4. 3. Imputing connections of random gene networks from time series data using ANNs

    University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Sofia Andersson; [2022]
    Keywords : artificial neural networks; ANNs; gene regulatory networks; GRNs; imputation; gene regulatory network imputation; GRN imputation; CNNs; convolutional neural network; randomly generated networks; ternary classification; binary classification; network inference; Physics and Astronomy;

    Abstract : This thesis presents the architecture of a convolutional neural network which is trained to impute the connections of randomly generated gene regulatory networks under varying amounts of regularisation. The generated gene networks are simulated from 10 different starting conditions for each set of connections in order to obtain multiple time series. READ MORE

  5. 4. A pipeline for the identification and examination of proteins implicated in frontotemporal dementia

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Katharina Waury; [2020]
    Keywords : Bioinformatics; Proteomics; Dementia; FTD; Biomarker; Machine Learning; Random Forest; R; Pipeline;

    Abstract : Frontotemporal dementia is a neurodegenerative disorder with high heterogeneity on the genetic, pathological and clinical level. The familial form of the disease is mainly caused by pathogenic variants of three genes: C9orf72, MAPT and GRN. READ MORE

  6. 5. Patterning of the neural tube: A 3D computational modelling approach

    University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Ariane Ernst; [2019]
    Keywords : gene regulatory networks; neural tube patterning; patterning of the neural tube; dopaminergic neurons; parkinson s disease; computational modelling; stem cell; GRN; Biology and Life Sciences; Physics and Astronomy;

    Abstract : Neurodegenerative diseases such as Parkinson’s can be treated with stem-cell derived specialized neurons. In order to achieve precise directed neural differentiation in vitro we need to understand the gene regulatory mechanisms behind in vivo neural tube patterning. READ MORE