Essays about: "Gabriel Tidestav"

Found 2 essays containing the words Gabriel Tidestav.

  1. 1. Chemical design, synthesis and biological evaluation of novel proteolysis targeting chimeras (PROTACs) for the degradation of NUDT5

    University essay from Uppsala universitet/Preparativ läkemedelskemi

    Author : Gabriel Tidestav; [2020]
    Keywords : protac; proteolysis targeting chimera; targetted protein degradation; nudt5; breast cancer; e3 ligase; ligands; vhl; crbn; theophylline;

    Abstract : Proteolysis targeting chimeras (PROTACs) represent a new modality in drug design. They are bifunctional molecules; with one end, they bind to a protein of interest, and with the other end, they bind to endogenous E3 ligases. READ MORE

  3. 2. Antibody drug conjugates (ADC) : Current status and mapping of ADC:s in clinical programs

    University essay from Uppsala universitet/Institutionen för teknikvetenskaper

    Author : Samantha Congreve; Reham Faris Elias; Gabriel Tidestav; Venus Zafranian; [2018]
    Keywords : ADC; antibody; drug; conjugate; biopharmaceuticals; structure; linker; payload; target; conjugation; market;

    Abstract : A literature study was performed on a new type of cancer medicine: antibody drug conjugates, or ADCs. These consist of a monoclonal antibody, chemically linked to a cytotoxic agent. What makes them unique is their selective toxicity against cancer cells. READ MORE