Essays about: "Galectins"

Showing result 1 - 5 of 7 essays containing the word Galectins.

1. 1. Exploring a unique pocket in Galectin-8N by the synthesis of D-galactoside-based benzimidazole inhibitors

   University essay from Lunds universitet/Centrum för analys och syntes

   Author : Sid Bartold; [2023]
   Keywords : organic chemistry; synthesis; gal; gal-8; gal-8N; galectin; galectin-8; galectin-8N; inhibitor; drug development; benzimidazole; galactoside; carbohydrate; carbohydrate chemistry; Suzuki-coupling; Chemistry;

   Abstract : Galectins are a family of glycan-binding proteins where galectin-8 is a part of the subgroup known as tandem-repeat type galectins. Galectin-8 is composed of two homologous CRDs, one N- and one C-terminal CRD. As it stands now, galectin-8N has been found to bind to a larger number of glycans than galectin-8C. READ MORE

3. 2. Design, synthesis, and evaluation of 1-phenylethanol and C2 threitol derivatives as non-pyranose galactose-mimicking inhibitors of Galectin-3

   University essay from Lunds universitet/Centrum för analys och syntes

   Author : Qrystal Cruz Giron; [2023]
   Keywords : Galectin-3; Galectin-3 inhibitor; 1-phenylethanol; C2 threitol derivative; galactose-mimicking inhibitor; organic chemistry; Chemistry;

   Abstract : Galectins are cytosolic protein family involved in several biological functions such as cell differentiation, cell migration and apoptosis amongst many others. Their presence is also substantial in diseases including acute inflammation, fibrosis, allergies, and cancer. READ MORE

4. 3. The Effect of Using DMSO as a Cosolvent for Ligand Binding Studies

   University essay from Lunds universitet/Biofysikalisk kemi

   Author : Simon Birgersson; [2019]
   Keywords : Galectins; Nuclear Magnetic Resonance; NMR; Biophysical Chemistry; Relaxation; CPMG; ITC; Biofysikalisk Kemi; Kärnmagnetisk resonans; Technology and Engineering; Chemistry; Biology and Life Sciences;

   Abstract : DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. READ MORE

5. 4. Investigation of α-thioaryl galactopyranosides to improve affinity towards Galectin-9N

   University essay from Lunds universitet/Kemiska institutionen

   Author : Sofi Gummesson; [2018]
   Keywords : organic chemistry; organisk kemi; Chemistry;

   Abstract : Galectins are a family of carbohydrate recognition proteins involved in modulation of cell signaling and cell adhesion. galectin-9 especially is involved in regulation of the immune response. In this work, galectin-9N inhibitors have been designed, synthesized and evaluated. READ MORE

6. 5. Synthesis of fluorescent carbohydrate coumarin hybrids via a three-component reaction : nanomolar galectin-3 inhibitor

   University essay from Lunds universitet/Kemiska institutionen

   Author : Shaun Hoang; [2013]
   Keywords : Organisk kemi; Chemistry;

   Abstract : Galectins play an important role in inflammation, immunity, cancer progression and are potential targets for novel anti-cancer and anti-inflammatory compounds. Coumarin thiodigalacoside hydrid had proved to be potent, nanomolar, and selective inhibitor of galectin-3. READ MORE