Essays about: "Gene networks"

Showing result 11 - 15 of 52 essays containing the words Gene networks.

  1. 11. Imputing connections of random gene networks from time series data using ANNs

    University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Sofia Andersson; [2022]
    Keywords : artificial neural networks; ANNs; gene regulatory networks; GRNs; imputation; gene regulatory network imputation; GRN imputation; CNNs; convolutional neural network; randomly generated networks; ternary classification; binary classification; network inference; Physics and Astronomy;

    Abstract : This thesis presents the architecture of a convolutional neural network which is trained to impute the connections of randomly generated gene regulatory networks under varying amounts of regularisation. The generated gene networks are simulated from 10 different starting conditions for each set of connections in order to obtain multiple time series. READ MORE

  3. 12. Modelling of gene regulatory and spatial mechanisms which pattern the early human neural tube

    University essay from Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

    Author : Fredrik Bertilsson; [2022]
    Keywords : Biophysics; systems biology; gene regulatory networks; neural tube; isthmic organizer; midbrain-hindbrain boundary; WNT; FGF; morphogens; reaction-diffusion; finite-difference; 3D modelling; Physics and Astronomy;

    Abstract : Tissue patterning during development is thought to be driven largely by gene regulatory responses to spatial gradients of molecular signals, known as morphogens. In this thesis, early patterning of the human neural tube is studied using two different gene regulatory network models. READ MORE

  4. 13. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles

    University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

    Author : Marc Pielies Avellí; [2022]
    Keywords : Cancer Driver CD Gene; Histone Post-Translational Modifications PTMs ; Convolutional Neural Networks CNNs .; Physics and Astronomy;

    Abstract : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. READ MORE

  5. 14. Generation of induced pluripotent stem cells (iPSCs) lines deficient for genes associated with neurodevelopmental diseases using CRISPR/Cas9 technology

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Claudia De Guidi; [2021]
    Keywords : ;

    Abstract : Induced pluripotent stem cells (iPSCs) can self-renew and differentiate into many other cell types. IPSCs are derived from somatic cells, and upon reprogramming, they share an expression profile similar to embryonic stem cells (ESCs). READ MORE

  6. 15. Segmentation and Prediction of Mutation Status of Malignant Melanoma Whole-slide Images using Deep Learning

    University essay from Lunds universitet/Avdelningen för Biomedicinsk teknik

    Author : Elin Johansson; Fanny Månefjord; [2021]
    Keywords : deep learning; image analysis; malignant melanoma; tissue segmentation; mutation classification; Inception v3; Technology and Engineering;

    Abstract : Malignant melanoma is an aggressive type of skin cancer. Gene mutations can make the disease progress faster, but specialised treatment exists. Today, gene mutations are detected with DNA-analysis which is costly and time-consuming. READ MORE