Essays about: "HER2"

Showing result 1 - 5 of 21 essays containing the word HER2.

  1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    University essay from Uppsala universitet/Theranostics

    Author : Astrid Haraldsson; [2023]
    Keywords : PNA; pretargeting; cancer therapy; cytotoxic payload;

    Abstract : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. READ MORE

  3. 2. Using Generative Adversarial Networks for H&E-to-HER2 Stain Translation in Digital Pathology Images

    University essay from Linköpings universitet/Institutionen för medicinsk teknik

    Author : William Tirmén; [2023]
    Keywords : Machine learning; Artificial intelligence; Digital pathology; Image processing; Generative adversarial networks; Image-to-image translation;

    Abstract : In digital pathology, hematoxylin & eosin (H&E) is a routine stain which is performed on most clinical cases and it often provides clinicians with sufficient information for diagnosis. However, when making decisions on how to guide breast cancer treatment, immunohistochemical staining of human epidermal growth factor 2 (HER2 staining) is also needed. READ MORE

  4. 3. Automated HER2 Scoring of Breast Cancer Tissue using Upconverting Nanoparticle Images

    University essay from Lunds universitet/Matematik LTH

    Author : Adam Belfrage; Alexander Wik; [2022]
    Keywords : HER2-scoring; image analysis; interpretability; digital pathology; computer aided pathology; whole slide imaging; ASCO-guidelines; singular value decomposition; shape models; Bayesian classification; Biology and Life Sciences; Medicine and Health Sciences; Technology and Engineering; Mathematics and Statistics;

    Abstract : Computer aided pathology is becoming more and more of a requirement within pathology due to increased demand of individualised treatments and personalised medicine. Because of the advance of digital pathology in recent years, where a high resolution camera acquire images of microscope slides, pathologists can now assess tissue samples in digital images. READ MORE

  5. 4. The density of CD163+ macrophages in different subtypes of breast cancer

    University essay from Örebro universitet/Institutionen för medicinska vetenskaper

    Author : Julia Andersson; [2022]
    Keywords : breast cancer; molecular subtypes; macrophages; immunohistochemistry; CD163;

    Abstract : Introduction Breast cancer is the most common cancer among women in Sweden and world-wide. Immunohistochemical (IHC) expression of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki-67 is routinely performed for diagnostic and prognostic purposes. READ MORE

  6. 5. Development of an AVI-tagged phagemid vector

    University essay from KTH/Proteinvetenskap

    Author : Barathram Swaminathan; [2022]
    Keywords : phage display; affibody; directed evolution; protein engineering; protein interactions; fagdisplay; affibody; riktad evolution; protein engineering; proteininteraktioner;

    Abstract : Fagmider är ett kraftfullt verktyg som använts för att uttrycka heterologa proteiner på fagvirus i metoder som exempelvis riktad evolution via fagdisplay av proteinbinliotek. Monovalent uttryck genom fagemider lider av ett överflöd av kala fager som är svåra att rensa bort. READ MORE