Essays about: "Half-Life extension"

Found 4 essays containing the words Half-Life extension.

  1. 1. Optimization of immunotherapeutic relevant ABD-derived affinity proteins for prolonged serum half-life

    University essay from KTH/Proteinvetenskap

    Author : Ebba Bergström; [2022]
    Keywords : Half-Life extension; Human serum Albumin HSA ; Interleukin 17c IL17c ; ABD-Derived Affinity ProTeins ADAPT ; Protein-based drugs.;

    Abstract : Marknaden för proteinbaserade läkemedel, de så kallade biologiska läkemedlen, är idag en industri som omsätter miljarder. Ett vanligt sätt att utveckla dessa läkemedel på är med hjälp av monoklonala antikroppar då de kan binda till sitt mål med hög specificitet. READ MORE

  3. 2. Production and Evaluation of a Bombesin Analogue Conjugated to the Albumin-Binding Domain and DOTA for Prostate Cancer Radiotherapy

    University essay from KTH/Proteinvetenskap

    Author : Fredrika Landmark; [2021]
    Keywords : bombesin; prostate cancer; radiotherapy; human serum albumin; half-life extension; bombesin; prostatacancer; radioterapi; humant serumalbumin; halveringstidsförlängning;

    Abstract : Prostate cancer is one of the most common types of cancer worldwide and claims hundreds of thousands of lives annually. Currently the most common treatment for prostate cancer is external beam radiotherapy, however, this treatment comes with serious side effects since it lacks selectivity for the cancer cells. READ MORE

  4. 3. Selection and characterization of bispecific ADAPT molecules for enhanced biodistribution in cancer therapy

    University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

    Author : Jesper Borin; [2020]
    Keywords : ABD; ADAPT; HER2; CEACAM6; HSA; Phage display; Cancer therapy; Spatial bispecificity; Half-life extension; Biodistribution;

    Abstract : Established biopharmaceuticals such as antibodies and derivatives thereof are relatively large. In cancer therapy, this creates a steep drug concentration gradient within tumors, leaving cells far from blood vessels effectively untreated. READ MORE

  5. 4. Study of Proton Emission in Complex Nuclei

    University essay from Lunds universitet/Matematisk fysik; Lunds universitet/Fysiska institutionen

    Author : Jonatan Adolfsson; [2016]
    Keywords : Nuclear physics; Nuclear theory; Nuclei far from stability; Proton decay; Cobalt-53; Physics and Astronomy;

    Abstract : In a recent experiment, the partial half-life ([i]t[/i][sub]1/2[/sub]) of proton emission from the [i]I[/i][sup]π[/sup] = 19/2[sup]-[/sup] state of [sup]53[/sup]Co was accurately measured. A previous estimate is [i]t[/i][sub]1/2[/sub] ~ 17 s. READ MORE