Essays about: "Heterodimerization"

Found 2 essays containing the word Heterodimerization.

1. 1. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?

   University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

   Author : Micaela Andersson; [2022]
   Keywords : Deorphanization; Heterodimerization; High-throughput screening; Orphan G-protein Coupled receptor; Pseudogenes; Reversed pharmacology;

   Abstract : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. READ MORE

3. 2. Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130

   University essay from Institutionen för medicinsk biokemi och mikrobiologi

   Author : Marwa Malki; [2010]
   Keywords : Female infertility; leukemia inhibitory factor; mutation; blastocyst implantation; genotyping.;

   Abstract : About 30 % of all infertile couples suffer from infertility of an unexplained cause. Leukemia inhibitory factor (LIF) is a glycoprotein produced by the endometrium and is an important cytokine in the implantation process. LIF exerts its biological functions through heterodimerization of its two receptors: LIF receptor (LIFR) and gp130. READ MORE