Essays about: "Huntington’s disease"

Showing result 1 - 5 of 7 essays containing the words Huntington’s disease.

1. 1. Transcriptional basis of Huntington’s Disease: Gene expression analysis indicate increased immune responses in the brain and mitochondrial dysfunction in adipose tissues of HD model mouse

   University essay from KTH/Proteinvetenskap

   Author : Intisar Salim; [2023]
   Keywords : Huntington’s Disease; mRNA-seq; tissue specific gene expression; cerebrospinal fluid; biomarker; Huntingtons sjukdom; mRNA-seq; vävnadsspecifik genexpression; cerebrospinalvätska; biomarkör;

   Abstract : Huntingtons sjukdom (HD) är ett neurodegenerativt tillstånd som orsakas av mutationer i huntingtin gen (Htt), och resulterar till upprepade glutamin (polyQ) i Htt-proteinet. Muterad Htt kan inte vika sig ordentligt och börjar därför aggregera i celler. READ MORE

3. 2. Evaluation of mechanisms for accessing intracellular targets for protein-based drugs

   University essay from Uppsala universitet/Avdelningen för farmaceutisk biokemi

   Author : Sonav Jindi Elias; [2021]
   Keywords : intracellular target; neuronal uptake; biological drug; receptor mediated uptake; cell-penetrating peptides;

   Abstract : Over the years, biological drugs have evolved and have made breakthroughs in diseases associated with extracellular proteins. However, intracellular proteins that cause disease progression are still largely inaccessible. READ MORE

4. 3. Huntingtin gene profiling, towards allele-specific treatment

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Mimmi Håkansson; [2020]
   Keywords : Huntington’s disease; huntingtin lowering; allele-selective; HD animal models; Huntingtons sjukdom; huntingtin sänkning; allel-specifik; Huntington djurmodeller;

   Abstract : Huntington diseases(HD) is a fatal autosomal neurodegenerative genetic disorder, caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, resulting in a toxic gain-of-function in the mutant huntingtin protein(mHTT). To date, there is no approved treatment to either cure or halt the course of HD. READ MORE

5. 4. Effects of herpes simplex virus 1 (HSV-1) infection on nuclear amyloid aggregation

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Maria Arone Blanco; [2018]
   Keywords : Huntington’s disease; Spinocerebellar ataxia; Amyloids; Protein aggregation; Herpes Simplex Virus 1; HSV-1; Virus infection; oligonucleotides; Filter retardation Assay; Dot Blot.; Huntingtons sjukdom; Spinocerebellära ataxier; Amyloider; Protein aggregering; Herpes Simplex Virus 1; HSV-1; Virus infektion; Oligonukleotider; Filter retardation Assay; Dot Blot.;

   Abstract : Huntington’s disease (HD) and Spinocerebellar ataxia (SCA) are incurable neurodegenerative diseases that affect the central nervous system. Amyloids, highly organized protein aggregates, are a hallmark for many neurodegenerative diseases. The presence and accumulation of amyloids are toxic and constitute the major cause of neuron cell death. READ MORE

6. 5. Amyloid Nucleation in Presence of Crowders

   University essay from Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

   Author : Jonas Wessén; [2014]
   Keywords : nucleation; molecular self-assembly; protein physics; statistical mechanics; thermodynamics; fibrilation kinetics; Monte Carlo; Huntington s; Parkinson s; Alzheimer s; molecular crowding; amyloid fibrils; amyloid; protein aggregation; Physics and Astronomy;

   Abstract : During the last few years, crowding effects on the physics of proteins has become an increasingly popular topic of research. This is is because most biological processes involving proteins naturally take place in a crowded environment, e.g. in the cellular environment where macromolecules may occupy 30% of the volume. READ MORE