Essays about: "Huntington s Disease"
Found 5 essays containing the words Huntington s Disease.
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1. Transcriptional basis of Huntington’s Disease: Gene expression analysis indicate increased immune responses in the brain and mitochondrial dysfunction in adipose tissues of HD model mouse
University essay from KTH/ProteinvetenskapAbstract : Huntingtons sjukdom (HD) är ett neurodegenerativt tillstånd som orsakas av mutationer i huntingtin gen (Htt), och resulterar till upprepade glutamin (polyQ) i Htt-proteinet. Muterad Htt kan inte vika sig ordentligt och börjar därför aggregera i celler. READ MORE
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2. Huntingtin gene profiling, towards allele-specific treatment
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : Huntington diseases(HD) is a fatal autosomal neurodegenerative genetic disorder, caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, resulting in a toxic gain-of-function in the mutant huntingtin protein(mHTT). To date, there is no approved treatment to either cure or halt the course of HD. READ MORE
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3. Effects of herpes simplex virus 1 (HSV-1) infection on nuclear amyloid aggregation
University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)Abstract : Huntington’s disease (HD) and Spinocerebellar ataxia (SCA) are incurable neurodegenerative diseases that affect the central nervous system. Amyloids, highly organized protein aggregates, are a hallmark for many neurodegenerative diseases. The presence and accumulation of amyloids are toxic and constitute the major cause of neuron cell death. READ MORE
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4. A1M, Hb and tryptophan metabolism in R6/2 mouse model of Huntington’s disease
University essay from Lunds universitet/LäkarutbildningenAbstract : Neurotoxic metabolites generated from tryptophan metabolism are increasingly regarded as a pathogenic mechanism in neurological and psychiatric disease including Huntington’s disease (HD). Specifically, the tryptophan-derived neurotoxin 3-hydroxykynurenine (3-HK) accumulates in HD brain and is capable of damaging neurons through excessive ROS-production and oxidative stress. READ MORE
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5. Physiotherapy for Patients with Huntington´s Disease : Effects of a Treatment Program with focus on balance and transitions and the Intercorrelation between Assessment Tools
University essay from SjukgymnastikAbstract : Objective: To evaluate the effect of a physiotherapeutic exercise programme for patients with Huntington´s Disease (HD) concerning motor function and disability, balance and fall related self-efficacy, and to investigate the correlation between the seven assessment tools. Participants: Twelve persons with genetically confirmed HD at an early or middle stage of the disease and with a mean age of 52 (16) years. READ MORE