Essays about: "Huntington s disease"

Found 5 essays containing the words Huntington s disease.

1. 1. Transcriptional basis of Huntington’s Disease: Gene expression analysis indicate increased immune responses in the brain and mitochondrial dysfunction in adipose tissues of HD model mouse

   University essay from KTH/Proteinvetenskap

   Author : Intisar Salim; [2023]
   Keywords : Huntington’s Disease; mRNA-seq; tissue specific gene expression; cerebrospinal fluid; biomarker; Huntingtons sjukdom; mRNA-seq; vävnadsspecifik genexpression; cerebrospinalvätska; biomarkör;

   Abstract : Huntingtons sjukdom (HD) är ett neurodegenerativt tillstånd som orsakas av mutationer i huntingtin gen (Htt), och resulterar till upprepade glutamin (polyQ) i Htt-proteinet. Muterad Htt kan inte vika sig ordentligt och börjar därför aggregera i celler. READ MORE

3. 2. Huntingtin gene profiling, towards allele-specific treatment

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Mimmi Håkansson; [2020]
   Keywords : Huntington’s disease; huntingtin lowering; allele-selective; HD animal models; Huntingtons sjukdom; huntingtin sänkning; allel-specifik; Huntington djurmodeller;

   Abstract : Huntington diseases(HD) is a fatal autosomal neurodegenerative genetic disorder, caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, resulting in a toxic gain-of-function in the mutant huntingtin protein(mHTT). To date, there is no approved treatment to either cure or halt the course of HD. READ MORE

4. 3. Effects of herpes simplex virus 1 (HSV-1) infection on nuclear amyloid aggregation

   University essay from KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Author : Maria Arone Blanco; [2018]
   Keywords : Huntington’s disease; Spinocerebellar ataxia; Amyloids; Protein aggregation; Herpes Simplex Virus 1; HSV-1; Virus infection; oligonucleotides; Filter retardation Assay; Dot Blot.; Huntingtons sjukdom; Spinocerebellära ataxier; Amyloider; Protein aggregering; Herpes Simplex Virus 1; HSV-1; Virus infektion; Oligonukleotider; Filter retardation Assay; Dot Blot.;

   Abstract : Huntington’s disease (HD) and Spinocerebellar ataxia (SCA) are incurable neurodegenerative diseases that affect the central nervous system. Amyloids, highly organized protein aggregates, are a hallmark for many neurodegenerative diseases. The presence and accumulation of amyloids are toxic and constitute the major cause of neuron cell death. READ MORE

5. 4. A1M, Hb and tryptophan metabolism in R6/2 mouse model of Huntington’s disease

   University essay from Lunds universitet/Läkarutbildningen

   Author : Sylvia Karlberg; [2012]
   Keywords : Huntington s Disease; kynurenine; tryptophan metabolism; A1M; Alpha-1-microglobulin; hemoglobin; neurology; neurobiology; neurochemistry; immune system; Medicine and Health Sciences;

   Abstract : Neurotoxic metabolites generated from tryptophan metabolism are increasingly regarded as a pathogenic mechanism in neurological and psychiatric disease including Huntington’s disease (HD). Specifically, the tryptophan-derived neurotoxin 3-hydroxykynurenine (3-HK) accumulates in HD brain and is capable of damaging neurons through excessive ROS-production and oxidative stress. READ MORE

6. 5. Physiotherapy for Patients with Huntington´s Disease : Effects of a Treatment Program with focus on balance and transitions and the Intercorrelation between Assessment Tools

   University essay from Sjukgymnastik

   Author : Anna Ingrid Camilla Ekwall; [2010]
   Keywords : Huntington s disease; Physiotherapy; Motor function; Disability; Balance; Fall- related self efficacy;

   Abstract : Objective: To evaluate the effect of a physiotherapeutic exercise programme for patients with Huntington´s Disease (HD) concerning motor function and disability, balance and fall related self-efficacy, and to investigate the correlation between the seven assessment tools. Participants: Twelve persons with genetically confirmed HD at an early or middle stage of the disease and with a mean age of 52 (16) years. READ MORE