Essays about: "Isothermal Titration Calorimetry"

Found 3 essays containing the words Isothermal Titration Calorimetry.

  1. 1. The Effect of Using DMSO as a Cosolvent for Ligand Binding Studies

    University essay from Lunds universitet/Biofysikalisk kemi

    Author : Simon Birgersson; [2019]
    Keywords : Galectins; Nuclear Magnetic Resonance; NMR; Biophysical Chemistry; Relaxation; CPMG; ITC; Biofysikalisk Kemi; Kärnmagnetisk resonans; Technology and Engineering; Chemistry; Biology and Life Sciences;

    Abstract : DMSO sees common application as a solvent for studies of synthetic molecules in biological systems, in fields such as drug design. Despite this, the possibility and nature of solvent interactions with both synthetic ligand and their target macromolecules is widely unexamined. READ MORE

  3. 2. A calorimetric study of α-synuclein fibril formation & peptide induced vesicle leakage

    University essay from Lunds universitet/Kemiska institutionen

    Author : Emil Axell; [2017]
    Keywords : Differential Scanning Calorimetry; ITC; Isothermal Titration Calorimetry; Parkinson; α-synuclein; Alpha synuclein; DSC; Melittin; Vesicles; biochemistry; biokemi; Chemistry;

    Abstract : The small protein α-synuclein is strongly associated with Parkinson’s disease. This protein is found in inclusion bodies, named lewy bodies inside neurons of people suffering from the disease. α-synuclein is very abundant in the human brain, and its normal function is still elusive and unclear. READ MORE

  4. 3. In vitro studies of Thiopurine S-Methyltransferase: Ligand binding interactions and development of a new enzymatic activity assay for TPMTwt, TPMT*6 and TPMT*8

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi; Linköpings universitet/Tekniska fakulteten

    Author : Lovisa Hemmingsson; Johan Klasén; [2015]
    Keywords : Thiopurine S-Methyltransferase; 6-mercaptourine; methotrexate; isothermal titration calorimetry; fluorescence spectroscopy;

    Abstract : Acute lymphoblastic leukemia, one of the most malignant cancer forms in children is commonly treated with the thiopurine 6-mercaptopurine (6-MP) in combination with a high dose of methotrexate (MTX). 6-Mercaptopurine is in the body metabolized by the enzyme thiopurine S-methyltransferase (TPMT). READ MORE