Essays about: "KINASE INHIBITOR"

Showing result 1 - 5 of 17 essays containing the words KINASE INHIBITOR.

  1. 1. Combining doxorubicin and gemcitabine with targeted drugs as a treatment option for high-risk neuroblastoma

    University essay from KTH/Proteinvetenskap

    Author : Alexandra Johannesson; [2023]
    Keywords : neuroblastoma; doxorubicin; gemcitabine; targeted drugs; ATM; neuroblastom; doxorubicin; gemcitabin; målinriktade läkemedel; ATM;

    Abstract : Neuroblastom är en barncancer som uppstår ur det sympatiska nervsystemet och drabbar omkring 15 barn i Sverige varje år. Högriskvarianten är associerad med mycket hög dödlighet och risk för återfall, vilket tros ha att göra med att tumörernas ovanligt heterogena sammansättning tillåter resistenta subpopulationer att motstå konventionella behandlingsmetoder. READ MORE

  3. 2. Bioinformatics analysis on the drug design supporting systems

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Emilia Guszpit; [2023]
    Keywords : ;

    Abstract : This research project investigates the interactions of staurosporine, a potent kinase inhibitor, with 11 ligands, highlighting its role in drug design and bioinformatics. Focusing on the selectivity and promiscuity of staurosporine in binding to protein kinases, the study employs the MANORAA database for data extraction. READ MORE

  4. 3. The effect of GSK-3 inhibitor SB216763 on the expression and secretion of IL-8 in THP-1 ASC GFP macrophages cells

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Umaimah Hassen; [2022]
    Keywords : ;

    Abstract : Inflammation is a part of the innate immune system. It protects the body against foreign invaders such as bacteria and viruses. Inflammation helps to restore the body by removing harmful stimuli and starting the healing process. READ MORE

  5. 4. The GSK-3 inhibitor has no effect on production of IL-1β in LPS- and Nigericin-stimulated THP-1 macrophages

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Jessica Halan Söderberg; [2022]
    Keywords : ;

    Abstract : Inflammation is the body's natural defense reaction and is known since ancient times. The inflammation is divided into two main phases, acute and chronic inflammation dependent on the process and cellular mechanisms of the inflammation. READ MORE

  6. 5. GSK-3 post-transcriptionally regulates TNF-α biosynthesis in THP-1 macrophages

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Raghad Alghazali; [2022]
    Keywords : ;

    Abstract : Few things are more fascinating than finding new interactions between previously unrelated pathways. Glycogen synthase kinase-3 (GSK-3), a ubiquitous kinase initially known for its role in regulating glycogen metabolism, has recently been found to be an indispensable regulator of the TLR4-mediated inflammatory response. READ MORE