Essays about: "LC-MS MS in drug"

Showing result 1 - 5 of 13 essays containing the words LC-MS MS in drug.

  1. 1. Creating a High-Throughput Workflow for Automated Peptide Characterization using LC-MS

    University essay from Lunds universitet/Centrum för analys och syntes

    Author : Sara Forsberg; [2023]
    Keywords : High-throughput analysis; Impurity profiling; UHPLC-HRMS; Peptide characterization; Peptide descriptors; Analytical chemistry; Technology and Engineering;

    Abstract : In the early stage of a drug discovery project, there is a need for efficient methods that can analyse peptides in short time. This includes methods that confirm the peptide’s identity and estimates its relative purity in an efficient and reliable way. READ MORE

  3. 2. Exploratory study of ion pair liquid chromatography separation methods and sample preparation procedures – for quantification of amount 5’capped and uncapped mRNA

    University essay from Karlstads universitet/Institutionen för ingenjörs- och kemivetenskaper (from 2013)

    Author : Felicia Lindström; [2023]
    Keywords : ;

    Abstract : Using ion pair chromatography, separation and analysis of shorter mRNA fragments was possible. The aim of the study was to develop a separation method for quantitation of 5’capped versus uncapped mRNA. Cleavage of mRNA was performed by complementary probes and the enzyme RNase H which created shorter mRNA fragments containing the 5’ end. READ MORE

  4. 3. Production, in vitro modification, and interaction analysis of a hydroxyproline-dependent protein

    University essay from Uppsala universitet/Biokemi

    Author : Milica Plavsic; [2023]
    Keywords : protein production optimisation; recombinant expression; bioreactor; prolyl hydroxylase; liquid chromatography mass spectrometry; microscale thermophoresis;

    Abstract : The development of a biologic protein involves different stages and becomes a highly complex process which can be costly and time consuming to scale up for industrial production. Therefore, optimization is a necessary part of the production process development to lower the production expenses. READ MORE

  5. 4. Expanding the application of a novel proteomics tool for drug target and mechanism identification

    University essay from Uppsala universitet/Analytisk kemi

    Author : Linnéa Yuan Andersson; [2022]
    Keywords : ;

    Abstract : In drug discovery and development, characterization of the drug targets and mechanisms of action is an essential step. ProTargetMiner is a publicly available proteome signature library of anticancer molecules and its automated bioinformatics platform can be used for drug target and mechanism deconvolution. READ MORE

  6. 5. Exploratory Analysis of Isoelectric Point Prediction with Simple Feature Encoding

    University essay from KTH/Tillämpad fysik

    Author : Henrik Söderhielm; [2022]
    Keywords : Applied Physics; Biotechnology; Tillämpad Fysik; Bioteknolgi;

    Abstract : Proteomics is the large scale study of proteins in biological systems such as those found in human cells. The understanding of proteomes, i.e. the complete set of proteins expressed by an organism, has especially useful applications in the medical field such as genetic research and drug discovery. READ MORE