Essays about: "LDHA"

Found 4 essays containing the word LDHA.

  1. 1. Investigating the cause of reduction of lactate production in Panc-1 cell lines when subjected to digitoxin

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Israel Tshibangu; [2021]
    Keywords : ;

    Abstract : Pancreatic ductal adenocarcinoma (PDAC) yet remains one of the top 10 most prevalent and top five most common cause of cancer-related deaths solely in the United States. Its metastatic deviation from most cancer types rends it one of the most subtle yet perturbating disease. READ MORE

  3. 2. Utilization of cancer-specific genome-scale metabolic models in pancreatic ductal adenocarcinomas for biomarkers discovery and patient stratification

    University essay from Högskolan i Skövde/Institutionen för biovetenskap

    Author : Mohamed Al Shobky; [2019]
    Keywords : Genome-Scale Metabolic Models; GEM; Pancreatic Ductal Adenocarcinomas; pancreatic cancer; cancer metabolism; biomarker; LDHA; L-lactate dehydrogenase A chain;

    Abstract : Pancreatic Ductal Adenocarcinomas initiates in the exocrine part of the pancreatic tissue and represents over 90% of all the pancreatic cancers. Pancreatic Ductal Adenocarcinomas are extremely aggressive and are one of the most lethal malignant neoplasms. The five-year relative survival is currently less than 8% of the patients. READ MORE

  4. 3. Construction of hpRNA expression vector for silencing a gene in Rhizopus oryzae

    University essay from Högskolan i Borås/Institutionen Ingenjörshögskolan

    Author : Kiran Kumar Penmatsa; Bharat Balu; [2012]
    Keywords : RNA interference; hpRNA; Silencing vector construction; Rhizopus oryzae; Ethanol; Lactic acid;

    Abstract : Depending on the previous research on LDHA gene silencing in Rhizopus oryzae CCUG 28959 through introduction of siRNA, a integral vector was constructed by inserting two copies of LDHA gene (by PCR cloning) in a fashion that it can express hpRNA in the transformed fungi, which will trigger the post transcriptional degradation of targeted mRNA through RNA degradation pathway which is known to be quelling in fungi.The vector was successfully designed with the LDHA gene, transformed in to the host organism, and also transferred to its progeny. READ MORE

  5. 4. RNA Silencing of Lactate Dehydrogenase Gene in Rhizopus oryzae

    University essay from Högskolan i Borås/Institutionen Ingenjörshögskolan

    Author : Neda Haghayegh Jahromi; Ali Hashemi Gheinani; [2011]
    Keywords : rna interference; knockdown; rhizopus oryzae; lactate dehydrogenase; lactic acid; ethanol; sirna;

    Abstract : RNA silencing with direct delivery of siRNA has been used to suppress ldhA gene expression in filamentous fungus Rhizopus oryzae. Here, for the first time we show that, introducing small interfering RNA which consequently forms silencing complexes can alter the gene expression and we report a significant reduction of lactic acid production for isolates containing short (25 nt) synthetic siRNA. READ MORE