Essays about: "MONOCLONAL ANTIBODIES"

Showing result 1 - 5 of 46 essays containing the words MONOCLONAL ANTIBODIES.

  1. 1. OPTIMIZATION OF CLONE SELECTION PLATFORM FOR PRODUCTION OF RECOMBINANT PROTEINS

    University essay from Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Author : Basel Yousef; [2024]
    Keywords : ;

    Abstract : Background  Biologics are type of proteins that can be produced by expression in a foreign host for medical healthcare applications in humans. Monoclonal antibodies (mAbs) are type of biologics that are designed to specifically bind to one target, with a purpose to inhibit a certain molecule that could be associated with a disease process. READ MORE

  3. 2. Establishment and Characterisation of new Immunoreagents for diagnosis of Ovarian cancer

    University essay from

    Author : Fanny Carlsson; [2023-04-19T12:15:23Z 2023-04-19T12:15:23Z 2022 2023]
    Keywords : ovarian; cancer; monoclonal; antibodies; biomarkers; CARM1; PARPi; EZH2i;

    Abstract : Ovarian cancer is the most lethal of all gynaecological cancers and it is often diagnosedat an advanced stage due to diffuse and only mild symptoms at early stages.Early detection is crucial to increase survival but high-grade serous ovarian cancer(HGSOC) often presents non-specific symptoms, such as loss of appetite, bloating ofabdomen and tiredness. READ MORE

  4. 3. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    University essay from Uppsala universitet/Institutionen för farmaci

    Author : Jonathan Efverström; [2023]
    Keywords : Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Abstract : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. READ MORE

  5. 4. Implementation of an automatic tangential flow filtration system for latex immunoassay production

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Filippa Stolpe; Sofia Kullander; [2023]
    Keywords : biotechnology; bioprocess; diagnostics; production; TFF; tangential flow filtration; blood clots; automation; antibodies; latex immunoassay; LIA;

    Abstract : To diagnose patients suffering from blood clotting disorders latex immununoassays (LIA) can be used. A time consuming manual tangential flow filtration (TFF) process suggests the implementation of an automatic TFF system to improve the efficiency, profitability, and expandability of the production facility of LIA at Nordic Biomarker. READ MORE

  6. 5. Identification of Monoclonal Antibodies:Peptide Mass Fingerprinting (PMF) with Matrix Assisted Laser Desorption/Ionization (MALDI), Time of Flight (ToF), Mass Spectrometry (MS) and Protein Peptide Mapping (PPM) with Capillary Electrophoresis (CE)

    University essay from KTH/Proteinvetenskap

    Author : Sofia Bengtsson; [2023]
    Keywords : Monoclonal Antibodies mAbs ; Matrix-Assisted Laser Desorption Ionization Time-of Flight Mass Spectrometry MALDI-ToF-MS ; In Source-Decay ISD ; Capillary Gel Electrophoresis CGE ; Capillary Zone Electrophoresis CZE ; Monoklonala antikroppar mAbs ; Matrix-Assisted Laser Desorption Ionization Time-of Flight Mass Spectrometry MALDI-ToF-MS ; In Source-Decay ISD ; Kapillärgelelektrofores CGE ; Kapillärzonelektrofores CZE ;

    Abstract : Antalet monoklonala antikroppar som används i läkemedel ökar kraftigt. Dessa läkemedel är dyra och risken för förfalskning är stor. Behovet att utveckla en metod för snabb och precis identifiering av monoklonala antikroppar är därför brådskande. READ MORE