Essays about: "Malignancies"

Showing result 1 - 5 of 24 essays containing the word Malignancies.

  1. 1. Investigating ERβ chromatin binding and its potential interaction with LRH-1 in an ovarian context

    University essay from KTH/Proteinvetenskap

    Author : Mick Phenphak; [2023]
    Keywords : estrogen receptor beta; ovary; granulosa cells; ChIP; qPCR; östrogen receptor beta; äggstock; granulosa celler; ChIP; qPCR;

    Abstract : Invasiv äggstockscancer anses vara en av de mest dödligaste gynekologiska maligniteterna. Granulosacelltumör i äggstocken är en sällsynt subtyp av äggstockstumör, som utgör 1–5% av alla äggstockstumörer. De kan kännetecknas av den långsamma tillväxthastigheten och produktionen av höga östrogennivåer. READ MORE

  3. 2. An Application of Cluster Analysis in Identifying and Evaluating Prognostic Subgroups for Therapy-Related Acute Myeloid Leukemia

    University essay from Uppsala universitet/Statistiska institutionen

    Author : Stefanie Antonilli; [2022]
    Keywords : AML; lymphoma; heterogeneous data; cluster analysis; k-prototypes algorithm;

    Abstract : Treatment for lymphoma with alkylating therapy is known to increase the risk of secondary malignancies such as Acute Myeloid Leukemia (AML), although the risk is not fully understood. This study investigates the characteristics of AML that arise after lymphoma treatment in contrastto AML cases without a prior lymphoma. READ MORE

  4. 3. Establishing a 7-plex panel for diagnostic markers of lung cancers using multiplexed IF solutions

    University essay from KTH/Proteinvetenskap

    Author : Katarina Åstrand; [2022]
    Keywords : Lung cancer; Immunostaining; Multiplexed tissue imaging; Immunofluorescence; TSA; Lungcancer; immunofärgning; multiplexed vävnads imaging; immunofluorescence; TSA;

    Abstract : Lungcancer är en heterogen sjukdom som kräver många histopatologiska analyser för att diagnostisera och behandla effektivt. Dessa analyser utförs för närvarande med singelplex immunohistokemi (IHC) vilket kräver mycket vävnadsprovmaterial om flera markörer behöver färgas för. READ MORE

  5. 4. Affibody phage display selections for lipid nanoparticle and affibody-mediated transient CAR T-cell therapy

    University essay from KTH/Proteinvetenskap

    Author : Tasnim Yasin Idris; [2022]
    Keywords : affibody; phage display; in vitro selection; CD5; CD8; CD19; CAR T-cell therapy.;

    Abstract : CAR T-cellbehandling är en immunterapi som har visat lovande resultat vid behandling av cancer. Trots det riktade immunsvaret som kan uppnås, betonar komplexiteten i tillverkningsprocessen och behandlingsproceduren det utrymme somm finns för förbättringar. READ MORE

  6. 5. Systems biology of deregulated splicing in cancer. A pan-cancer analysis of dysfunctional splicing machinery and alternative splicing events.

    University essay from

    Author : Leticia Castillon; [2021-08-06T14:57:24Z 2021-08-06T14:57:24Z 2021 2020]
    Keywords : multi-omics; splicing; alternative splicing; deep learning; cancer; transcriptome;

    Abstract : The deregulation or disruption of the splicing process has been shown to play a role in the onset, development, and even response to treatment of some malignancies. Partly due to our incomplete understanding of the mechanism and regulation behind splicing and alternative splicing, the importance of aberrant splicing in oncogenesis is not yet understood. READ MORE