Essays about: "Metabolomics"
Showing result 1 - 5 of 23 essays containing the word Metabolomics.
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1. Leveraging CNN for Automated Peak Picking in Untargeted Metabolomics without Parameter Dependencies
University essay from Göteborgs universitet/Institutionen för data- och informationsteknikAbstract : Metabolomics is a scientific discipline that involves the thorough analysis of small molecules, known as metabolites, found within a biological system. Furthermore, liquid chromatography-mass spectrometry (LC-MS) is a commonly used analytical technique in metabolomics for analysing biological samples due to its broad coverage of the measurable metabolome. READ MORE
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2. Using metabolic profiles to screen for novel compounds in deep-sea sponges
University essay from Uppsala universitet/Institutionen för farmaceutisk biovetenskapAbstract : The chemical diversity of the phylum Porifera have provided marine natural products (MNPs) such as alkaloids, terpenoids and peptides with ranging biological activity. Every two days a novel compound deriving from sponges are discovered. READ MORE
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3. Metabolomics database resolver
University essay from Uppsala universitet/Institutionen för biologisk grundutbildningAbstract : Metabolomics is a rising field combining bioinformatics and cheminformatics together. A major component of research is having a reliable data source, which usually comes in the form of metabolomic databases. READ MORE
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4. Optimization of a Methodology for Cell Based Untargeted Metabolomics with UHPLC-Q-ToF-MS
University essay from Uppsala universitet/Analytisk farmaceutisk kemiAbstract : Metabolomics is the study of small molecules (molecular weight < 1500 Da) in a biological system and can provide relevant information about endpoints of biochemical pathways by establishing metabolic profiles for different sample cohorts and comparing these through multivariate data analysis. The aim of this thesis was to establish and test a suitable methodology for cell-based untargeted metabolomics, utilizing UHPLC-MS. READ MORE
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5. Predicting Mechanisms of Toxicity for Drug Development
University essay from Göteborgs universitet/Institutionen för data- och informationsteknikAbstract : The aim of this thesis is to predict different mechanisms of toxicity from the metabolomic response of HepG2 liver cells. In order to utilize the metabolomic data the a semisupervised machine learning approach is investigated, namely the cluster-then-label approach. READ MORE