Essays about: "NMDA"

Showing result 1 - 5 of 9 essays containing the word NMDA.

1. 1. Promote neuroprotection and axonal outgrowth in the central and peripheral neural system

   University essay from Uppsala universitet/Institutionen för medicinsk cellbiologi

   Author : Elin Petersson; [2021]
   Keywords : Spinal cord injury; interleukin-1 receptor antagonist; excitotoxicity; qPCR; dorsal root ganglion.;

   Abstract : Acute spinal cord injury is often caused by collisions with motor vehicles, falls or violence. This injury could potentially lead to paraplegia or tetraplegia, causing great economic and personal loss. The patophysiology is biphasic, with primary and secondary mechanisms. READ MORE

3. 2. When the brain loses TrkBactivation : The effects of ketamine on BDNF-TrkB neurotransmission in animal models of depression

   University essay from Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

   Author : Hanna Sädbom-Williams; [2021]
   Keywords : Ketamine; Depression; BDNF; TrkB; Animal model; Hippocampus; Prefrontal cortex;

   Abstract : Ketamine is a non-competitive N-methyl-D-aspartate (NMDA)-channel blocker that has recently shown promise in the treatment of major depressive disorder, distinguishing itself from classical anti-depressants through its rapid and lasting effects when given at sub-anaesthetic doses. Animal models of depression are commonly used to research individual mechanisms of action and this literature review aimed to investigate how ketamine influences BDNF-TrkB neurotransmission in the hippocampus and prefrontal cortex within animal models of depression. READ MORE

4. 3. Ketamine for treatment-resistant depression : Moving away from conventional antidepressants

   University essay from Högskolan i Skövde/Institutionen för biovetenskap

   Author : Emma-Clara Blom; [2021]
   Keywords : Ketamine; antidepressant; treatment-resistant depression; NMDA-receptor antagonist; glutamate;

   Abstract : An increasing amount of research suggests Ketamine in subanaesthetic doses to be an effective antidepressant for Major Depressive Disorder (MDD) and Treatment-Resistant Disorder (TRD). After the finding that NMDA-receptor antagonists may hold antidepressant effect, several studies have suggested Ketamine to have great effect in relief of depressive symptoms. READ MORE

5. 4. Simulating Facilitation in a Spiking Neural Network

   University essay from Lunds universitet/Examensarbeten i molekylärbiologi

   Author : Alexander Kuzmin; [2020]
   Keywords : Biology and Life Sciences;

   Abstract : Many insects are able to detect, isolate and track small targets that move quickly against a dynamic background. This ability is enabled by a group of neurons called small target motion detectors (STMD). These neurons, among other properties, have a type of short term memory called response facilitation. READ MORE

6. 5. Ketamine for depression : The role of dissociative effects

   University essay from Högskolan i Skövde/Institutionen för biovetenskap

   Author : Jakob Broström; [2020]
   Keywords : antidepressant; depression; dissociation; ketamine; major depressive disorder; NMDA receptor antagonist; placebo; psychedelics;

   Abstract : Several trials have reported rapid antidepressant response from the anesthetic drug ketamine although the mechanism behind this effect is not fully understood. Research has focused mainly on ketamine’s action in the brain, including its effects on chemical balance, connections between brain cells and networks, and cognition. READ MORE