Essays about: "Olle Nordesjö"

Found 1 essay containing the words Olle Nordesjö.

  1. 1. Searching for novel protein-protein specificities using a combined approach of sequence co-evolution and local structural equilibration

    University essay from Uppsala universitet/Institutionen för biologisk grundutbildning

    Author : Olle Nordesjö; [2016]
    Keywords : Biotechnology; Bioinformatics; Molecular Structure; Protein Conformation; Computing Methodologies; Protein-protein interaction; Binding affinity; Mutation analysis; Amino acid mutation; in-silico binding affinity prediction; Two-component regulatory system; Histidine Kinase; Response Regulator; Prediction; PhoQ; PhoP; Phosphatase;

    Abstract : Greater understanding of how we can use protein simulations and statistical characteristics of biomolecular interfaces as proxies for biological function will make manifest major advances in protein engineering. Here we show how to use calculated change in binding affinity and coevolutionary scores to predict the functional effect of mutations in the interface between a Histidine Kinase and a Response Regulator. READ MORE