Essays about: "Orphan Drugs"

Showing result 1 - 5 of 6 essays containing the words Orphan Drugs.

  1. 1. Orphan G-Protein Coupled Receptors : Can we deorphanize the remaining orphans despite all the challenges?

    University essay from Linköpings universitet/Institutionen för fysik, kemi och biologi

    Author : Micaela Andersson; [2022]
    Keywords : Deorphanization; Heterodimerization; High-throughput screening; Orphan G-protein Coupled receptor; Pseudogenes; Reversed pharmacology;

    Abstract : G-protein coupled receptors (GPCRs) play a key role in a broad range of biological processes by binding to a wide variety of signaling molecules, which have resulted in 34% of all FDA-approved drugs which target GPCRs. The human genome encodes for approximately 800 GPCR members of which about 140 non-olfactory receptors remain orphans with an unknown function and endogenous ligand. READ MORE

  3. 2. Playing the European Postal Code Lottery? : Analysis of Time to Market of new Drugs on the European Market

    University essay from Uppsala universitet/Nationalekonomiska institutionen

    Author : Anna Rumetshofer; [2019]
    Keywords : Time to Market; Launch Time; Fixed Effects; Drug Characteristics; Country Characteristics;

    Abstract : This thesis seeks to investigate the vastly varying time to market of newly approved drugs across Europe. Firtsly, I use a country fixed effects model on data of newly approved drugs from 2014 to 2017 from 18 European countries. READ MORE

  4. 3. What should an Optimal and Fair Introduction Process for Orphan Drugs look like? : Experiences and Views of County Officials and Politicians in Northern Sweden

    University essay from Umeå universitet/Epidemiologi och global hälsa

    Author : Carl Lundberg; [2017]
    Keywords : Orphan drugs; introduction; Northern Sweden;

    Abstract : Background: Increasing costs and quantities of orphan drugs within the European market has led to much debate in Sweden on how they should be handled within the existing reimbursement system. Previously, there has been little research looking at local and regional handling of and implications of these issues when it comes to decision-making, financing, and access. READ MORE

  5. 4. An Analysis of the Decision-making Process of the TLV and the Willingness to Pay for Healthcare in Sweden

    University essay from Göteborgs universitet/Graduate School

    Author : Jens Dahlstrand; Fredrik Sandberg; [2016-10-03]
    Keywords : ;

    Abstract : The Dental and Pharmaceutical Benefits Agency (TLV) is the Swedish government agency who decides if a new medicine should be included in the benefit scheme or not. This study investigates which implicit factors influence the agency’s reimbursement decisions and how the TLV values different properties of a medicine. READ MORE

  6. 5. Alternative legal incentives for antibiotic research and development : The role and function of legal mechanisms

    University essay from Uppsala universitet/Juridiska institutionen

    Author : Anna Sundberg; [2016]
    Keywords : ;

    Abstract : In Europe there are 25 000 deaths per year as a result of antimicrobial resistance and in the world the estimated annual number of deaths is 700 000. By 2050, it has been predicted that 10 million people per year could die from being resistant to antibiotic compounds. READ MORE