Essays about: "PBPK"

Showing result 1 - 5 of 7 essays containing the word PBPK.

1. 1. An Interactive MIDD Framework for Evaluation and Comparison of PBPK Model Performance

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Dylan Garamani; [2022]
   Keywords : MIDD; PBPK; QSP; PK; GUI;

   Abstract : Modeling and simulation are becoming indispensable elements in drug development. Mechanistic modeling is susceptible to impacting several drug development and regulatory decisions through extrapolations beyond clinically researched scenarios by using its capacity to incorporate diverse data to provide a detailed and comprehensive understanding of a physiological and biological system. READ MORE

3. 2. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Rosa Kafey; [2022]
   Keywords : PBPK; MODELLS;

   Abstract : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. READ MORE

4. 3. Infrastructure for quality control of handling of reference data in PBPK projects using PK-Sim

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Yasmine Sundelin Tjärnström; [2022]
   Keywords : Pharmacometrics; PBPK; R; QC;

   Abstract : PBPK modelling is used in drug development to predict how the drug isaffected by the body. These models are built on physiology and describeprocesses like absorption, distribution, metabolism and excretion.Simulations of these processes can take place in the software PK-Sim forinstance. READ MORE

5. 4. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Albin Leding; [2021]
   Keywords : Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

   Abstract : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. READ MORE

6. 5. Models for predicting efflux transport over the blood-brain barrier

   University essay from Uppsala universitet/Institutionen för farmaci

   Author : Marjaneh Janani; [2020]
   Keywords : efflux transport; brain; blood-brain-barrier; Verapamil; Risperidone; Prazosin;

   Abstract : Aim: The general aim of this research is development and evaluation of novel methods for predicting active transport over the human blood-brain-barrier (BBB), while this project specifically aims to i) review the literature and select suitable methods and substrates, ii) develop models for determining in vitro kinetic properties of selected compounds, analyze the in vitro data using the developed models and to use Maximum Transport Activity (MTA) approach (Karlgren et al., 2012), iii) perform Physiology Based Pharmacokinetic (PBPK) modelling and compare to in vivo literature data. READ MORE